The widespread prevalence of methicillin-resistant Staphylococcus aureus (MRSA) in community and healthcare settings has driven the urgent search for novel antibacterial agents. Mangrove sediments are an underexplored source of antimicrobial-producing …
Publications
- Publications
Implications of Glucagon‐Like Peptide‐1 Signaling for Hemophilic Arthropathy, Joint Inflammation, and Cartilage Degeneration: A Narrative Review
Introduction Hemophilic arthropathy (HA) is a progressive, inflammatory joint disease that develops despite effective control of bleeding in people with hemophilia (PWH). Increasing evidence suggests that HA is initiated and …
The automation of the azapeptide submonomer synthesis procedure is reported. All steps for on‐resin aza‐amino acid synthesis, including semicarbazone incorporation, alkylation, deprotection, and semicarbazide acylation were adapted for use on …
- Publications
Molecular-Weight-Dependent Effects of Fish-Derived Peptide Biostimulants on Carbon–Nitrogen Metabolism and Anthocyanin Biosynthesis in Purple Lettuce
Fish-processing by-products represent a potential source of peptide-based plant biostimulants, but the relationships between peptide molecular characteristics and plant metabolic responses remain poorly defined. This study evaluated the effects of …
- Publications
Starvation transforms signal encoding in C. elegans thermoresponsive neurons and suppresses heat avoidance via bidirectional glutamatergic and peptidergic signaling
. During early food deprivation (1-hr off food), the thermoresponsive sensory neurons AWCs mediate robust heat-evoked reversals over a broad range of stimulus intensities via glutamate and FLP-6 neuropeptide signaling, …
Aging populations face a growing burden of neurodegenerative disease and behavioral decline. The microbiota is increasingly implicated in host physiology, highlighting an urgent need to understand how gut microbes modulate …
- Publications
Real-World Effectiveness, Documented Adverse Events, and Treatment Adherence of Semaglutide and Liraglutide in Omani Patients: A Retrospective Observational Study
Background: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are widely used in obesity and type 2 diabetes mellitus (T2DM), but comparative real-world evidence from the Middle East remains limited. We compared …
- Publications
Annotated GenBank Sequence for the piggyBac XY-VO Metabolic Chassis Vector (PEEK-BHS V8 Framework)
Description Overview This dataset contains the fully annotated, complete nucleotide sequence in GenBank (.gb) format for the piggyBac XY-VO Final Metabolic Chassis Vector, designed in alignment with the PEEK-BHS V8 …
- Publications
Weight Regain After Discontinuation of GLP-1 and GIP/GLP-1 Receptor Agonists: A Systematic Review
Background: Weight regain and loss of cardiometabolic benefit commonly follow the withdrawal of glucagon-like peptide-1 receptor agonists (GLP-1RAs) and dual glucose-dependent insulinotropic polypeptide/GLP-1 receptor agonists, yet maintenance strategies are incompletely …
- Publications
Short-term clinical efficacy and recorded adverse events of semaglutide combined with dapagliflozin in patients with type 2 diabetes mellitus and chronic kidney disease
Type 2 diabetes mellitus (T2DM) complicated by chronic kidney disease (CKD) is associated with persistent hyperglycemia, progressive renal impairment, systemic inflammation, and an increased risk of adverse clinical outcomes. Sodium–glucose …