Clinical Trials

A Clinical Trial Evaluating SCB-219M in in Chemotherapy-induced Thrombocytopenia (CIT)

Trial ID: NCT05426369   Registry: ClinicalTrials.gov

Intervention: Recombinant Human Tumor Necrosis Factor Receptor II -Fc-TPO Mimetic Peptide Fusion Protein

Condition: Chemotherapy-induced Thrombocytopenia (CIT)

Sponsor: Sichuan Clover Biopharmaceuticals, Inc.

Locations: 1 active-listed location

A Clinical Trial to Assess the Effect of AP-Brain Collagen Peptides on the Improvement of Attention, Focus, and Memory in Stressed But Otherwise Healthy Individuals

Trial ID: NCT07572240   Registry: ClinicalTrials.gov

Intervention: AP-Brain Collagen Peptide

Condition: Healthy, Stress

Sponsor: Rousselot BVBA

Locations: 8 active-listed locations

A MultIceNTER Phase I Peptide VaCcine Trial for the Treatment of H3-Mutated Gliomas

Trial ID: NCT04808245   Registry: ClinicalTrials.gov

Intervention: Tecentriq 1200 MG in 20 ML Injection, H3K27M peptide vaccine, Imiquimod (5%)

Condition: Newly Diagnosed H3-mutated Glioma

Sponsor: German Cancer Research Center

Locations: 8 active-listed locations

A Phase 1/2 Study of OBI-992 in Subjects With Advanced Solid Tumors

Trial ID: NCT06480240   Registry: ClinicalTrials.gov

Intervention: OBI-992

Condition: Advanced Solid Tumor

Sponsor: OBI Pharma, Inc

Locations: 8 active-listed locations

A Phase I Trial of IMA970A Plus Montanide in Combination With Durvalumab (Anti-PD-L1)

Trial ID: NCT06218511   Registry: ClinicalTrials.gov

Intervention: Peptide-based hepatocellular carcinoma vaccine IMA970A, Durvalumab, Montanide (Adjuvant)

Condition: Hepatocellular Carcinoma

Sponsor: National Cancer Institute, Naples

Locations: 1 active-listed location

A Phase I/II, Dose Finding and Optimization Study of [177Lu]Lu-NeoB in Combination With Capecitabine in Patients With GRPR+, ER+, HER2- Metastatic Breast Cancer After Progression on Previous Endocrine Therapy in Combination With a CDK4/6 Inhibitor.

Trial ID: NCT06247995   Registry: ClinicalTrials.gov

Intervention: [68Ga]Ga-NeoB, [177Lu]Lu-NeoB, Capecitabine

Condition: Breast Cancer

Sponsor: Novartis Pharmaceuticals

Locations: 74 active-listed locations

A Series of Pilot Studies to Evaluate the haemoDynamic and mEtabolic Effects oF apelIn aNd rElaxin

Trial ID: NCT03449251   Registry: ClinicalTrials.gov

Intervention: Apelin, Relaxin, Normal saline, Verapamil, LN Monomethyl arginine

Condition: Cardiovascular Diseases, Type 2 Diabetes Mellitus

Sponsor: Cambridge University Hospitals NHS Foundation Trust

Locations: 1 active-listed location

A Study of ELI-002 7P in Subjects With KRAS/NRAS Mutated Solid Tumors

Trial ID: NCT05726864   Registry: ClinicalTrials.gov

Intervention: ELI-002 7P

Condition: Pancreatic Ductal Adenocarcinoma, Colorectal Cancer, KRAS G12D, KRAS G12R, KRAS G12V, KRAS G12A, KRAS G12C, KRAS G12S, KRAS G13D, NRAS G12D, NRAS G12R, NRAS G12V, NRAS G12C, NRAS G12S

Sponsor: Elicio Therapeutics

Locations: 28 active-listed locations

A Vaccine (Neoantigen-Targeted ppDC) for the Treatment of H3 G34-mutant Diffuse Hemispheric Glioma

Trial ID: NCT06342908   Registry: ClinicalTrials.gov

Intervention: Biospecimen Collection, Dendritic Cell Therapy, Leukapheresis, Magnetic Resonance Imaging, Poly ICLC

Condition: Diffuse Hemispheric Glioma, H3 G34-Mutant

Sponsor: Jonsson Comprehensive Cancer Center

Locations: 1 active-listed location

A Vaccine (PDS0101) Alone or in Combination With Pembrolizumab for the Treatment of Locally Advanced Human Papillomavirus-Associated Oropharynx Cancer

Trial ID: NCT05232851   Registry: ClinicalTrials.gov

Intervention: Liposomal HPV-16 E6/E7 Multipeptide Vaccine PDS0101, Pembrolizumab, Computed Tomography, FDG-Positron Emission Tomography, Biospecimen Collection, Biopsy

Condition: Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Human Papillomavirus-Related Carcinoma, Locally Advanced Oropharyngeal Carcinoma, Stage IVA Oropharyngeal (p16-Negative) Carcinoma AJCC v8, Stage IVB Oropharyngeal (p16-Negative) Carcinoma AJCC v8

Sponsor: Mayo Clinic

Locations: 1 active-listed location

A Vaccine (PDS0101) and Chemoradiation for the Treatment of Stage IB3-IVA Cervical Cancer, the IMMUNOCERV Trial

Trial ID: NCT04580771   Registry: ClinicalTrials.gov

Intervention: Cisplatin, Liposomal HPV-16 E6/E7 Multipeptide Vaccine PDS0101, Radiation Therapy

Condition: Locally Advanced Cervical Squamous Cell Carcinoma, Not Otherwise Specified, Stage IB3 Cervical Cancer FIGO 2018, Stage II Cervical Cancer FIGO 2018, Stage IIA Cervical Cancer FIGO 2018, Stage IIA1 Cervical Cancer FIGO 2018, Stage IIA2 Cervical Cancer FIGO 2018, Stage IIB Cervical Cancer FIGO 2018, Stage III Cervical Cancer FIGO 2018, Stage IIIA Cervical Cancer FIGO 2018, Stage IIIB Cervical Cancer FIGO 2018, Stage IIIC Cervical Cancer FIGO 2018, Stage IIIC1 Cervical Cancer FIGO 2018, Stage IIIC2 Cervical Cancer FIGO 2018, Stage IVA Cervical Cancer FIGO 2018

Sponsor: M.D. Anderson Cancer Center

Locations: 1 active-listed location

Adjuvant PVX-410 Vaccine and Durvalumab in Stage II/III Triple Negative Breast Cancer

Trial ID: NCT02826434   Registry: ClinicalTrials.gov

Intervention: PVX-410, Durvalumab, Hiltonol

Condition: Breast Cancer

Sponsor: Massachusetts General Hospital

Locations: 5 active-listed locations

Akershus Cardiac Examination 4 Study

Trial ID: NCT05699564   Registry: ClinicalTrials.gov

Intervention: Early biomarker-based cardiological assessment

Condition: Heart Failure, Tachypnea

Sponsor: University Hospital, Akershus

Locations: 1 active-listed location

Bacteremia From Periodontal Treatment to Elucidate the Underpinnings of Sepsis

Trial ID: NCT04565691   Registry: ClinicalTrials.gov

Intervention: Non-surgical periodontal treatment

Condition: Bacteremia, Periodontal Diseases, Sepsis, Heart Diseases

Sponsor: Malmö University

Locations: 1 active-listed location

Bariatric Surgery vs. Semaglutide vs. Tirzepatide

Trial ID: NCT06803888   Registry: ClinicalTrials.gov

Intervention: Bariatric Surgery, Semaglutide, Tirzepatide

Condition: Obesity and Obesity-related Medical Conditions

Sponsor: Ali Aminian

Locations: 1 active-listed location

Beijing Osteoporosis With Neurological Disorders in Epigenetic Changes Study

Trial ID: NCT03401619   Registry: ClinicalTrials.gov

Intervention: Exercise，Nutrition，Bisphosphonates，Statins，Calcitonin,Vitamin D，et al.

Condition: Osteoporosis，Neurological Disorders

Sponsor: Peking University Third Hospital

Locations: 1 active-listed location

Beta Cell Function in Type 2 Diabetes: Differential Effects of SGLT2 Inhibitors and GLIP-Receptor Agonists

Trial ID: NCT07325435   Registry: ClinicalTrials.gov

Intervention: SGLT-2 inhibitor, GLP1-RA

Condition: Type 2 Diabetes (T2DM)

Sponsor: MaryAnn Banerji

Locations: 1 active-listed location

Brain Activation and Satiety in Children 2

Trial ID: NCT04520490   Registry: ClinicalTrials.gov

Intervention: Family Based Behavioral Treatment, Exenatide 2 mg [Bydureon], Placebo

Condition: Childhood Obesity

Sponsor: Seattle Children's Hospital

Locations: 1 active-listed location

CAR-DC Vaccine and ICIs in Local Advanced/Metastatic Solid Tumors

Trial ID: NCT05631899   Registry: ClinicalTrials.gov

Intervention: KRAS-EphA-2-CAR-DC, Abraxane, Cyclophosphamide, Anti-PD-1 antibody, Anti-CTLA4 Monoclonal Antibody

Condition: Solid Tumor, Adult, EphA2 Overexpression, KRAS G12V, KRAS G12C, KRAS G12D

Sponsor: Chinese PLA General Hospital

Locations: 1 active-listed location

CMV-MVA Triplex Vaccination of Stem Cell Donors in Preventing CMV Viremia in Participants With Allogeneic Transplant

Trial ID: NCT03560752   Registry: ClinicalTrials.gov

Intervention: Multi-peptide CMV-Modified Vaccinia Ankara Vaccine

Condition: Accelerated Phase CML, BCR-ABL1 Positive, Acute Lymphoblastic Leukemia in Remission, Acute Myeloid Leukemia in Remission, Chronic Lymphocytic Leukemia, Chronic Phase CML, BCR-ABL1 Positive, Cytomegalovirus Positive, Donor, Hematopoietic Cell Transplant Recipient, Hodgkin Lymphoma, Myelodysplastic Syndrome, Myelodysplastic/Myeloproliferative Neoplasm, Non-Hodgkin Lymphoma, Myelofibrosis, Hematopoietic and Lymphoid Cell Neoplasm

Sponsor: City of Hope Medical Center

Locations: 1 active-listed location

Cancer Peptides Plus GM-CSF and Adjuvant in Breast Cancer

Trial ID: NCT04270149   Registry: ClinicalTrials.gov

Intervention: ESR1 peptide vaccine

Condition: Breast Cancer

Sponsor: Herbert Lyerly

Locations: 1 active-listed location

Clinical Phase II/III Trial of Ustekinumab to Treat Type 1 Diabetes (UST1D2)

Trial ID: NCT03941132   Registry: ClinicalTrials.gov

Intervention: Ustekinumab, Placebo

Condition: Type 1 Diabetes Mellitus

Sponsor: University of British Columbia

Locations: 2 active-listed locations

Clinical Trial of Gammora® Plus Antiretroviral Treatment for HIV

Trial ID: NCT06799650   Registry: ClinicalTrials.gov

Intervention: Gammora®

Condition: HIV Seropositivity

Sponsor: Federal University of São Paulo

Locations: 1 active-listed location

Closed-loop for People Living With Cystic Fibrosis Related Diabetes

Trial ID: NCT05562492   Registry: ClinicalTrials.gov

Intervention: CamAPS FX, Standard insulin therapy with CGM

Condition: Cystic Fibrosis-related Diabetes

Sponsor: University of Cambridge

Locations: 14 active-listed locations

Comparative Effectiveness and Safety of Four Second Line Pharmacological Strategies in Type 2 Diabetes Study

Trial ID: NCT05220917   Registry: ClinicalTrials.gov

Intervention: SGLT2 inhibitor, DPP-4 inhibitor, GLP-1RA, 2nd generation SU

Condition: Cardiovascular Events, Type2 Diabetes, Renal Disease

Sponsor: Brigham and Women's Hospital

Locations: 1 active-listed location

Comparing the Performance of Serum Creatinine and Cystatin C-based GFR Estimations in Predicting Directly Measured GFR in Patients With or Without Nephrotic Syndrome

Trial ID: NCT06797609   Registry: ClinicalTrials.gov

Intervention: Sample analyses

Condition: Nephrotic Syndrome

Sponsor: Mario Negri Institute for Pharmacological Research

Locations: 2 active-listed locations

Direct Measurement of Microstructure of Ingestive Behaviour After Initiation of GLP-1 Receptor Agonist Treatment at Maximum Dose (DIGRAT)

Trial ID: NCT07457424   Registry: ClinicalTrials.gov

Intervention: semaglutide 1 mg weekly injection

Condition: Metabolic Disease, Obesity & Overweight

Sponsor: University College Dublin

Locations: 1 active-listed location

Dose Escalation Study of Immunomodulatory Nanoparticles

Trial ID: NCT04751786   Registry: ClinicalTrials.gov

Intervention: PRECIOUS-01

Condition: Advanced Solid Tumor

Sponsor: Radboud University Medical Center

Locations: 1 active-listed location

Dry Needling and Shoulder Muscle Blood Flow, Motions, and Pain Sensitivity in Individuals with Shoulder Pain

Trial ID: NCT05596240   Registry: ClinicalTrials.gov

Intervention: Dry Needling, Sham Dry Needling

Condition: Dry Needling, Shoulder Pain

Sponsor: Texas Woman's University

Locations: 1 active-listed location

ETAPA I: Peptide-based Tumor Associated Antigen Vaccine in GBM

Trial ID: NCT05283109   Registry: ClinicalTrials.gov

Intervention: Tumor Associated Antigen Peptide Vaccine P30-EPS Vaccine, Hiltonol

Condition: Glioma, Malignant

Sponsor: Mustafa Khasraw, MBChB, MD, FRCP, FRACP

Locations: 1 active-listed location

Early Phase Clinical Trial About Therapeutic Biological Product Mix for Treating CEA Positive Rectal Cancer

Trial ID: NCT02403505   Registry: ClinicalTrials.gov

Intervention: CEA protein antigen plus BCG Vaccine Mix for percutaneous use

Condition: Rectal Cancer

Sponsor: Han Xu, M.D., Ph.D., FAPCR, Sponsor-Investigator, IRB Chair

Locations: 4 active-listed locations

Effect of Metreleptin Therapy in the Treatment of Severe Insulin Resistance

Trial ID: NCT00085982   Registry: ClinicalTrials.gov

Intervention: Metreleptin

Condition: Severe Insulin Resistance

Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Locations: 1 active-listed location

Effects of Antagonizing the Ghrelin Receptor on Brain Food Cue Reactivity in Obesity

Trial ID: NCT06845033   Registry: ClinicalTrials.gov

Intervention: LEAP2 infusion, Placebo

Condition: Obesity and Overweight

Sponsor: University Hospital, Gentofte, Copenhagen

Locations: 1 active-listed location

Effects of Different Remineralization Agents on the Progression of Non-Cavitated Approximal Carious Lesions in Primary Teeth: A Randomized Clinical Trial

Trial ID: NCT07431463   Registry: ClinicalTrials.gov

Intervention: P11-4 + NaF Varnish, Silver diamine fluoride, NaF Varnish Alone

Condition: Dental Caries

Sponsor: Izmir Katip Celebi University

Locations: 1 active-listed location

Effects of Long-Acting GLP-1 (Glucagon-like Peptide-1) or Dual Incretin (GLP-1 and GIP [Glucose-dependent Insulinotropic Peptide]) Modulation on Gastric Motor Functions

Trial ID: NCT06801015   Registry: ClinicalTrials.gov

Intervention: Semaglutide, Tirzepatide, Placebo

Condition: Obesity

Sponsor: Mayo Clinic

Locations: 1 active-listed location

Effects of P-TIOX and Tixel Combined on Reducing Eye Wrinkles

Trial ID: NCT07222176   Registry: ClinicalTrials.gov

Intervention: Split-Face Tixel Treatment With and Without Topical Peptide-Based Cosmeceutical (P-TIOX)

Condition: Periocular Fine Wrinkles

Sponsor: Main Line Center for Laser Surgery

Locations: 1 active-listed location

Effects of Rehabilitation and Supplementation With Hydrolyzed Collagen vs. Whey Protein on the Cardiopulmonary, Renal, Muscular, and Immunohematological Response of COPD Patients

Trial ID: NCT07011225   Registry: ClinicalTrials.gov

Intervention: Verisol Collagen 2,5 g/day, Peptech Collagen 2,5 g/day, Peptech Collagen 10 g/day, Pulmonary rehabilitation with aerobic and resistance training., Cardiorespiratory test

Condition: Collagen Supplementation, Whey Protein, Pulmonary Rehabilitation, COPD - Chronic Obstructive Pulmonary Disease

Sponsor: Federal University of São Paulo

Locations: 1 active-listed location

Effects of Vitamin D and Omega-3 Fatty Acids on Infectious Diseases and hCAP18 (VITAL Infection)

Trial ID: NCT01758081   Registry: ClinicalTrials.gov

Intervention: vitamin D3, omega-3 fatty acids (fish oil), Vitamin D3 placebo, fish oil placebo

Condition: Infections, Human Cathelicidin Antimicrobial Peptide (hCAP-18)

Sponsor: Brigham and Women's Hospital

Locations: 1 active-listed location

Efficacy and Safety of 177Lu-edotreotide PRRT in GEP-NET Patients

Trial ID: NCT03049189   Registry: ClinicalTrials.gov

Intervention: 177Lu-edotreotide PRRT, Everolimus, Amino-Acid Solution

Condition: Neuroendocrine Tumors

Sponsor: ITM Solucin GmbH

Locations: 52 active-listed locations

Evaluation of the Novel Therapeutic Hepatitis B Virus Synthetic Long Peptide Vaccination ISA104

Trial ID: NCT05841095   Registry: ClinicalTrials.gov

Intervention: ISA104, Placebo

Condition: Chronic Hepatitis b

Sponsor: Erasmus Medical Center

Locations: 1 active-listed location

First-in-Human Positron Emission Tomography Study Using the 18F-αvβ6-Binding-Peptide

Trial ID: NCT03164486   Registry: ClinicalTrials.gov

Intervention: 18F-αvβ6-BP

Condition: Breast Carcinoma, Colorectal Carcinoma, Lung Carcinoma, Metastatic Malignant Neoplasm in the Breast, Metastatic Malignant Neoplasm in the Colon, Metastatic Malignant Neoplasm in the Lung, Metastatic Malignant Neoplasm in the Rectum, Pancreatic Carcinoma

Sponsor: Julie L. Sutcliffe, Ph.D

Locations: 2 active-listed locations

Food Intake, Endocrine Factors and Brown Fat

Trial ID: NCT06285461   Registry: ClinicalTrials.gov

Intervention: Non-palatable meal, Palatable meal

Condition: Obesity

Sponsor: Turku University Hospital

Locations: 1 active-listed location

GLP-1 and Hypoglycemia

Trial ID: NCT01858896   Registry: ClinicalTrials.gov

Intervention: Glucagon-Like Peptide- 1 (GLP-1) infusion, Placebo Comparator: Saline Infusion

Condition: Type 2 Diabetes Mellitus

Sponsor: University of Maryland, Baltimore

Locations: 1 active-listed location

Gut Microbiome in AP Naive

Trial ID: NCT03414151   Registry: ClinicalTrials.gov

Intervention: Observation

Condition: Psychotic Disorder, Schizophrenia

Sponsor: Centre for Addiction and Mental Health

Locations: 1 active-listed location

Improvement of Immunologic and Molecular Techniques for the Diagnosis and Follow-up of Patients With Thrombotic Thrombocytopenic Purpura

Trial ID: NCT05046717   Registry: ClinicalTrials.gov

Intervention: ADAMTS13 Activity Assays

Condition: Acquired Thrombotic Thrombocytopenic Purpura

Sponsor: Fundación Española de Hematología y Hemoterapía

Locations: 6 active-listed locations

Improvement of Live Babies Rates After ICSI, Using cpFT

Trial ID: NCT04954274   Registry: ClinicalTrials.gov

Intervention: Cyclic peptide Fertiline

Condition: Infertility, Oocyte, Pregnancy

Sponsor: Assistance Publique - Hôpitaux de Paris

Locations: 1 active-listed location

Improving Cardiovascular Disease Diagnosis and Treatment in Kazakhstan Using Metabolic Correction With GLP-1 Drugs

Trial ID: NCT07303556   Registry: ClinicalTrials.gov

Intervention: Tirzepatide (Mounjaro), dapagliflozin, empagliflozin, metformin

Condition: Heart Failure, Diabete Type 2, Arterial Hypertension

Sponsor: Nazarbayev University

Locations: 1 active-listed location

Janus Kinase (JAK) Inhibitors to Preserve C-Peptide Production in New Onset Type 1 Diabetes (T1D)

Trial ID: NCT05743244   Registry: ClinicalTrials.gov

Intervention: Abrocitinib 200 MG Oral Tablet, Ritlecitinib, Placebo

Condition: Diabetes Mellitus, Type 1

Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Locations: 30 active-listed locations

LBBP as Initial Therapy in Patients With Non-ischemic Heart Failure and LBBB

Trial ID: NCT05572957   Registry: ClinicalTrials.gov

Intervention: Guideline-Directed Medical Therapy(GDMT), left bundle branch pacing combined with Guideline-Directed Medical Therapy(LBBP+GDMT)

Condition: Non-ischemic Cardiomyopathy, Heart Failure, Left Bundle-Branch Block

Sponsor: The First Affiliated Hospital with Nanjing Medical University

Locations: 6 active-listed locations

Low-Dose Dobutamine and Single-Dose Tocilizumab in Acute Myocardial Infarction With High Risk of Cardiogenic Shock

Trial ID: NCT05350592   Registry: ClinicalTrials.gov

Intervention: Tocilizumab, Dobutamine, NaCl 0.9%

Condition: Acute Myocardial Infarction, Cardiogenic Shock

Sponsor: Copenhagen University Hospital, Rigshospitalet

Locations: 1 active-listed location

Lutetium 177Lu-Edotreotide Versus Best Standard of Care in Well-differentiated Aggressive Grade-2 and Grade-3 GastroEnteroPancreatic NeuroEndocrine Tumors (GEP-NETs) - COMPOSE

Trial ID: NCT04919226   Registry: ClinicalTrials.gov

Intervention: 177Lu-Edotreotide (Peptide Receptor Radionuclide Therapy) PRRT, CAPTEM (Capecitabine and Temozolomide), Amino-Acid Solution, Everolimus, FOLFOX (Folinic acid + Fluorouracil + Oxaliplatin)

Condition: Neuroendocrine Tumors

Sponsor: ITM Solucin GmbH

Locations: 42 active-listed locations

MRI Assessment of Pancreatic Fat Changes and Islet Function Recovery After Bariatric Surgery in Obese Patients

Trial ID: NCT07464223   Registry: ClinicalTrials.gov

Intervention: Laparoscopic Sleeve Gastrectomy (LSG)

Condition: Obesity & Overweight, Type 2 Diabetes Mellitus (T2DM), Pancreatic Steatosis, Insulin Resistance

Sponsor: yu li，MD

Locations: 1 active-listed location

MUC1 Vaccine in Preventing Lung Cancer in Current and Former Smokers at High Risk for Lung Cancer

Trial ID: NCT03300817   Registry: ClinicalTrials.gov

Intervention: Laboratory Biomarker Analysis, MUC1 Peptide-Poly-ICLC Vaccine

Condition: Lung Carcinoma

Sponsor: National Cancer Institute (NCI)

Locations: 21 active-listed locations

Meningococcal Vaccination in Patients on Complement Inhibitors

Trial ID: NCT06906692   Registry: ClinicalTrials.gov

Intervention: Serum Bactericidal Assay

Condition: Myasthenia Gravis Generalised, Vaccination, Complement System, Neuromyelitis Optica Spectrum Disease (NMOSD)

Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Locations: 1 active-listed location

Metabolic Responses of Metformin and Genetic Polymorphisms of SLC22A1 Gene in PCOS

Trial ID: NCT05680805   Registry: ClinicalTrials.gov

Intervention: Metformin Hydrochloride

Condition: Polycystic Ovary Syndrome, Metformin

Sponsor: Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh

Locations: 1 active-listed location

Multi-Center Development of a Novel Diagnostic Test for Alzheimer's Disease

Trial ID: NCT03560960   Registry: ClinicalTrials.gov

Intervention: Pramlintide challenge test

Condition: Alzheimer Disease, Mild Cognitive Impairment

Sponsor: Boston University

Locations: 3 active-listed locations

Multi-antigen CMV-MVA Triplex Vaccine in Reducing CMV Complications in Patients Previously Infected With CMV and Undergoing Donor Hematopoietic Cell Transplant

Trial ID: NCT02506933   Registry: ClinicalTrials.gov

Intervention: Laboratory Biomarker Analysis, Multi-peptide CMV-Modified Vaccinia Ankara Vaccine, Placebo

Condition: Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Acute Lymphoblastic Leukemia in Remission, Acute Myeloid Leukemia in Remission, Chronic Lymphocytic Leukemia, Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Cytomegaloviral Infection, Hodgkin Lymphoma, Lymphadenopathy, Lymphoblastic Lymphoma, Myelodysplastic Syndrome, Myelofibrosis, Myeloproliferative Neoplasm, Non-Hodgkin Lymphoma

Sponsor: City of Hope Medical Center

Locations: 3 active-listed locations

Mutant CALR-peptide Based Vaccine in Patients With Mutated CALR Myeloproliferative Neoplasm

Trial ID: NCT05025488   Registry: ClinicalTrials.gov

Intervention: Peptide-based vaccine, Poly ICLC

Condition: Myelofibrosis, Essential Thrombocythemia, MPN

Sponsor: Marina Kremyanskaya

Locations: 1 active-listed location

Mutant KRAS -Targeted Long Peptide Vaccine for Patients at High Risk of Developing Pancreatic Cancer

Trial ID: NCT05013216   Registry: ClinicalTrials.gov

Intervention: Cohort A: Patients at high risk of developing pancreatic cancer., Cohort B: Patients must have evidence of a pancreatic cystic neoplasm

Condition: High Risk Cancer, Pancreatic Cancer

Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Locations: 1 active-listed location

N-terminal Pro-B-type Natriuretic Peptide (NT-proBNP) in Type 2 Diabetes Mellitus

Trial ID: NCT05745090   Registry: ClinicalTrials.gov

Condition: Type2diabetes, Heart Failure, Cardiovascular Complication

Sponsor: Singapore General Hospital

Locations: 1 active-listed location

NeoVax + CDX-301 and Nivolumab or Pembrolizumab in Melanoma

Trial ID: NCT04930783   Registry: ClinicalTrials.gov

Intervention: CDX-301, NEOVAX, Nivolumab, Pembrolizumab

Condition: Melanoma, Metastatic Melanoma

Sponsor: Dana-Farber Cancer Institute

Locations: 1 active-listed location

Optimization of Obesity for Total Knee Replacement With Glucagon-like Peptide-1 Receptor Agonist

Trial ID: NCT06807970   Registry: ClinicalTrials.gov

Intervention: Glucagon-like peptide-1 receptor agonists (GLP 1 RA), Control (Standard treatment)

Condition: Osteoarthritis (OA) of the Knee

Sponsor: The University of Hong Kong

Locations: 1 active-listed location

PEP-CMV in Recurrent MEdulloblastoma/Malignant Glioma

Trial ID: NCT03299309   Registry: ClinicalTrials.gov

Intervention: PEP-CMV

Condition: Recurrent Medulloblastoma, Recurrent Brain Tumor, Childhood, Malignant Glioma

Sponsor: Daniel Landi

Locations: 1 active-listed location

Personalized DC Vaccines in Non Small Cell Lung Cancer

Trial ID: NCT05195619   Registry: ClinicalTrials.gov

Intervention: Autologous dendritic cell vaccine loaded with personalized peptides (PEP-DC vaccine), Low dose cyclophosphamide

Condition: Non-small Cell Lung Cancer

Sponsor: Centre Hospitalier Universitaire Vaudois

Locations: 1 active-listed location

Personalized NeoAntigen Cancer Vaccine w RT Plus Pembrolizumab for Patients With Newly Diagnosed GBM

Trial ID: NCT02287428   Registry: ClinicalTrials.gov

Intervention: Radiation Therapy, Personalized NeoAntigen Peptides, Pembrolizumab, Temozolomide, Poly-ICLC

Condition: Glioblastoma

Sponsor: Dana-Farber Cancer Institute

Locations: 2 active-listed locations

Personalized PRRT of Neuroendocrine Tumors

Trial ID: NCT02754297   Registry: ClinicalTrials.gov

Intervention: 177Lu-Octreotate

Condition: Neuroendocrine Tumors, Carcinoid Tumor, Carcinoma, Neuroendocrine

Sponsor: CHU de Quebec-Universite Laval

Locations: 1 active-listed location

Personalized Vaccine With SOC Chemo Followed by Nivo in Pancreatic Cancer

Trial ID: NCT04627246   Registry: ClinicalTrials.gov

Intervention: Autologous Dendritic Cell Vaccine Loaded with Personalized Peptides (PEP-DC vaccine)

Condition: Pancreatic Adenocarcinoma

Sponsor: Centre Hospitalier Universitaire Vaudois

Locations: 1 active-listed location

Phase II Study to Evaluate Efficacy and Safety of AMP Peptide PL-5 in Mild Infections of Diabetic Foot Ulcers

Trial ID: NCT06189638   Registry: ClinicalTrials.gov

Intervention: Antimicrobial Peptide PL-5 Topical Spray and Placebo

Condition: Diabetic Foot Ulcers

Sponsor: Jiangsu ProteLight Pharmaceutical & Biotechnology Co., Ltd.

Locations: 3 active-listed locations

Point of Care NT-proBNP Testing for Suspected New Heart Failure Acute Care

Trial ID: NCT07793968   Registry: ClinicalTrials.gov

Intervention: NT-proBNP testing

Condition: Heart Failure

Sponsor: University of Stirling

Locations: 1 active-listed location

Pooled Mutant KRAS-Targeted Long Peptide Vaccine Combined With Nivolumab and Ipilimumab for Patients With Resected Mismatch Repair Protein (MMR-p) Colorectal and Pancreatic Cancer

Trial ID: NCT04117087   Registry: ClinicalTrials.gov

Intervention: KRAS peptide vaccine, Nivolumab, Ipilimumab

Condition: Colorectal Cancer, Pancreatic Cancer

Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Locations: 1 active-listed location

Prediction of ARrhythmic Events With Positron Emission Tomography II

Trial ID: NCT03493516   Registry: ClinicalTrials.gov

Intervention: PET scan quantifying sympathetic denervation using [18F]-LMI1195

Condition: Sudden Cardiac Arrest, Ischemic Cardiomyopathy, Congestive Heart Failure

Sponsor: State University of New York at Buffalo

Locations: 1 active-listed location

Pulmonary Fibrosis During Severe COVID-19 Pneumonia

Trial ID: NCT04987528   Registry: ClinicalTrials.gov

Intervention: Aminoterminal type III peptide of procollagen, Lung computed tomography

Condition: Severe Acute Respiratory Syndrome Coronavirus 2, Acute Respiratory Distress Syndrome, Pulmonary Fibrosis

Sponsor: Hôpital Européen Marseille

Locations: 1 active-listed location

REsynchronization Comparison In LBBB and Normal or Mildly Reduced VENTricular Function With CRT (REINVENT-CRT)

Trial ID: NCT05652218   Registry: ClinicalTrials.gov

Intervention: LB-CRT, BIV-CRT

Condition: Left Ventricular Ejection Fraction, Heart Failure (HF), Left Bundle-Branch Block

Sponsor: Inova Health Care Services

Locations: 2 active-listed locations

Repeat BCG Vaccinations for the Treatment of Established Type 1 Diabetes

Trial ID: NCT02081326   Registry: ClinicalTrials.gov

Intervention: Bacillus Calmette-Guérin, Saline injection

Condition: Diabetes Mellitus, Type One, Diabetes Mellitus, Type I, Autoimmune Diabetes, Covid19

Sponsor: Massachusetts General Hospital

Locations: 1 active-listed location

Rituximab-pvvr and Abatacept vs Rituximab-pvvr Alone in New Onset Type 1 Diabetes

Trial ID: NCT03929601   Registry: ClinicalTrials.gov

Intervention: Rituximab-pvvr, Abatacept, Sterile Sodium Chloride

Condition: Type 1 Diabetes Mellitus

Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Locations: 19 active-listed locations

SVN53-67/M57-KLH Peptide Vaccine in Treating Patients With Newly Diagnosed Multiple Myeloma Receiving Lenalidomide Maintenance Therapy

Trial ID: NCT02334865   Registry: ClinicalTrials.gov

Intervention: Incomplete Freund's Adjuvant, Laboratory Biomarker Analysis, Lenalidomide, Sargramostim, SVN53-67/M57-KLH Peptide Vaccine

Condition: Partial Response of Multiple Myeloma or Plasma Cell Leukemia, Plasma Cell Myeloma

Sponsor: Roswell Park Cancer Institute

Locations: 2 active-listed locations

Safety and Efficacy Study for DC Vaccine in Recurrent or Progressive High-grade Gliomas

Trial ID: NCT06253234   Registry: ClinicalTrials.gov

Intervention: personalized dendritic cell injection ZSNeo-DC1.1

Condition: WHO Grade III Gliomas, WHO Grade IV Gliomas

Sponsor: Beijing Tiantan Hospital

Locations: 1 active-listed location

Safety and Immunogenicity Trial of PepGNP-COVID19 Vaccine in Adults

Trial ID: NCT07183709   Registry: ClinicalTrials.gov

Intervention: PepGNP-COVID19, Sterile Water for Injection

Condition: COVID-19

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Locations: 3 active-listed locations

Safety and Immunogenicity of Personalized Genomic Vaccine and Tumor Treating Fields (TTFields) to Treat Glioblastoma

Trial ID: NCT03223103   Registry: ClinicalTrials.gov

Intervention: Poly-ICLC, Tumor Treating Fields, Peptides

Condition: Glioblastoma

Sponsor: Adilia Hormigo

Locations: 1 active-listed location

Safety, PK and PD Relationships of RLS-0071 in Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Trial ID: NCT06175065   Registry: ClinicalTrials.gov

Intervention: RLS-0071, Placebo

Condition: Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Sponsor: ReAlta Life Sciences, Inc.

Locations: 4 active-listed locations

Safety, Tolerability, Pharmacokinetics and Immunogenicity Study of GB002 Recombinant Peptide Inhalation Solution in Healthy Subjects

Trial ID: NCT06423261   Registry: ClinicalTrials.gov

Intervention: GB002 Recombinant Peptide Inhalation Solution, Placebo

Condition: Healthy

Sponsor: Zhejiang Echon Biopharm Limited

Locations: 1 active-listed location

Sepsis Associated Encephalopathy (SAE) Biomarkers

Trial ID: NCT03133208   Registry: ClinicalTrials.gov

Intervention: Blood draws

Condition: Sepsis, Altered Mental Status, Sepsis-Associated Delirium, Sepsis Associated Encephalopathy, Delirium, Sepsis Associated

Sponsor: University of Florida

Locations: 1 active-listed location

Serum IGF-1 and IGF-1Ec in Malignancy Assessment

Trial ID: NCT07151807   Registry: ClinicalTrials.gov

Condition: Cancer, Solid Tumor Malignancies, IGF1R, Solid Cancers

Sponsor: Çanakkale Onsekiz Mart University

Locations: 1 active-listed location

Study in Subjects With Mild-to-Moderate Alzheimer's Dementia

Trial ID: NCT05834296   Registry: ClinicalTrials.gov

Intervention: ALZN002 (autologous DCs pulsed with E22W mutant peptide)., Placebo

Condition: Alzheimer Disease

Sponsor: Alzamend Neuro, Inc.

Locations: 1 active-listed location

Study of PRRT in Metastatic, WHO Grade 1 or 2, SSTR Positive, GEP-NET Who Are Candidates for Cytoreductive Surgery

Trial ID: NCT04609592   Registry: ClinicalTrials.gov

Intervention: Lutathera, Gallium 68 Dotatate, Computed Tomography (CT), Magnetic Resonance Imaging (MRI), PET/CT

Condition: Gastroenteropancreatic Neuroendocrine Tumor

Sponsor: Stanford University

Locations: 1 active-listed location

Study of RV001V in Biochemical Failure Following Curatively Intended Therapy For Localized Prostate Cancer

Trial ID: NCT04114825   Registry: ClinicalTrials.gov

Intervention: RV001V, Placebo

Condition: Prostate Cancer Recurrent

Sponsor: RhoVac APS

Locations: 36 active-listed locations

Study on the Predictive Value of High-sensitivity Cardiac Troponin I, N-terminal Pro-B-natriuretic Peptide, and Soluble Suppression of Tumorigenesis-2 for Mortality and the Development of Cardiovascular Events in Patients With Type 2 Diabetes (Diabetes-CV)

Trial ID: NCT06902857   Registry: ClinicalTrials.gov

Condition: Type 2 Diabetes, Cardiovascular Complication

Sponsor: Istituto Nazionale di Ricovero e Cura per Anziani

Locations: 1 active-listed location

Subclinical Myocardial Dysfunction in Children With Wilson's Disease

Trial ID: NCT07765472   Registry: ClinicalTrials.gov

Intervention: Echocardiography, Electrocardiography, N-terminal pro b- type natriuretic peptide

Condition: Wilson's Disease, Myocardial Dysfunction, Children, Wilson Disease, Speckle Tracking Echocardiography, Electrocardiographic Changes

Sponsor: Hebatullah Fawzy

Locations: 2 active-listed locations

SurVaxM Vaccine Therapy and Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma

Trial ID: NCT02455557   Registry: ClinicalTrials.gov

Intervention: Laboratory Biomarker Analysis, Montanide ISA 51 VG, Sargramostim, SVN53-67/M57-KLH Peptide Vaccine, Temozolomide

Condition: Glioblastoma, Gliosarcoma

Sponsor: Roswell Park Cancer Institute

Locations: 5 active-listed locations

Targeted Alpha-emitter Therapy of PRRT Naïve and Previous PRRT Neuroendocrine Tumor Patients

Trial ID: NCT05153772   Registry: ClinicalTrials.gov

Intervention: AlphaMedix

Condition: Neuroendocrine Tumors

Sponsor: Orano Med LLC

Locations: 4 active-listed locations

Targeted Therapy and Avelumab in Merkel Cell Carcinoma

Trial ID: NCT04261855   Registry: ClinicalTrials.gov

Intervention: Avelumab, External Beam Radiation Therapy (EBRT), Lutetium-177 (177Lu)-DOTATATE

Condition: Metastatic Merkel Cell Carcinoma

Sponsor: Melanoma and Skin Cancer Trials Limited

Locations: 10 active-listed locations

The Effect of Healthy Nutrition and Functional Foods Education Based on the Health Promotion Model for Individuals With Type 2 Diabetes on Healthy Lifestyle Behaviors and Self-Efficacy in Diabetes: Randomized Controlled Study

Trial ID: NCT06721546   Registry: ClinicalTrials.gov

Intervention: Nursing interventions, reminder messages, Telephone counseling

Condition: Type 2 Diabetes Mellitus (T2DM)

Sponsor: Necmettin Erbakan University

Locations: 1 active-listed location

The Effect of Interventional Procedures on Serum CGRP and PACAP-38 Levels in Chronic Migraine

Trial ID: NCT07395908   Registry: ClinicalTrials.gov

Intervention: Greater occipital nerve Pulse radiofrequency, Greater occipital nerve block

Condition: Chronic Migraine Headache, Radiofrequency Ablation, Greater Occipital Nerve Block, Calcitonin Gene-related Peptide, Pacap-38

Sponsor: Aydin Adnan Menderes University

Locations: 1 active-listed location

The Effects of PeptiStrong and Whey on Muscle Function In Older Adults

Trial ID: NCT07528469   Registry: ClinicalTrials.gov

Intervention: PeptiStrong + whey protein, Whey protein

Condition: Healthy Ageing, Protein Supplementation, Muscle Health, Muscle Function, Hand Grip Strength, Longevity, Peptides

Sponsor: Nuritas Ltd

Locations: 1 active-listed location

The Impact of Acupuncture on Biomarkers of Brain Injury and Inflammatory Response in Migraine

Trial ID: NCT07292506   Registry: ClinicalTrials.gov

Intervention: Standard acupuncture, Electroacupuncture, Laser Acupuncture

Condition: Migraine, Migraine Headache, Migraine Headache, With or Without Aura, Migraine in Adults

Sponsor: University Medical Centre Ljubljana

Locations: 1 active-listed location

The R-E-V-I-V-A-L Study

Trial ID: NCT06992674   Registry: ClinicalTrials.gov

Intervention: Rimegepant, Placebo

Condition: Vestibular Migraine

Sponsor: Second Affiliated Hospital, Zhejiang University, School of Medicine

Locations: 1 active-listed location

The Safety and Tolerability of PGV001-based Personalized Multi-peptide Vaccines in the Adjuvant Setting.

Trial ID: NCT05010200   Registry: ClinicalTrials.gov

Intervention: PGV-001, Poly-ICLC, CDX-301

Condition: Prostate Cancer

Sponsor: Ashutosh Kumar Tewari

Locations: 1 active-listed location

The Very Large Database of Lipids

Trial ID: NCT01698489   Registry: ClinicalTrials.gov

Condition: Lipid Disorders and Lipid Measurement

Sponsor: Johns Hopkins University

Locations: 1 active-listed location

Triplex Vaccine in Preventing CMV Infection in Patients Undergoing Hematopoietic Stem Cell Transplantation

Trial ID: NCT04060277   Registry: ClinicalTrials.gov

Intervention: Letermovir, Multi-peptide CMV-Modified Vaccinia Ankara Vaccine, Placebo Administration

Condition: Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, Chronic Lymphocytic Leukemia, Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Hematopoietic and Lymphoid Cell Neoplasm, Hodgkin Lymphoma, Lymphoblastic Lymphoma, Myelodysplastic Syndrome, Myelofibrosis, Myeloproliferative Neoplasm, Non-Hodgkin Lymphoma

Sponsor: City of Hope Medical Center

Locations: 1 active-listed location

Urine Extracellular Vesicles: Non-invasive Biomarkers of Β-cell Function and Novel Therapeutic Agents in Diabetes

Trial ID: NCT06832215   Registry: ClinicalTrials.gov

Intervention: Blood and urine samples collection

Condition: Diabetes Mellitus, Type 1, Diabetes Mellitus

Sponsor: Unidade Local de Saúde de Coimbra, EPE

Locations: 1 active-listed location

Vaccine Therapy Plus Pembrolizumab in Treating Advanced Ovarian, Fallopian Tube, or Primary Peritoneal Cavity Cancer

Trial ID: NCT05920798   Registry: ClinicalTrials.gov

Intervention: Biopsy, Biospecimen Collection, Computed Tomography, Magnetic Resonance Imaging, Multi-epitope Folate Receptor Alpha-loaded Dendritic Cell Vaccine, Pembrolizumab, Pheresis

Condition: Fallopian Tube Carcinosarcoma, Primary Peritoneal Carcinosarcoma, Recurrent Fallopian Tube Carcinoma, Recurrent Fallopian Tube Clear Cell Adenocarcinoma, Recurrent Fallopian Tube Endometrioid Adenocarcinoma, Recurrent Fallopian Tube High Grade Serous Adenocarcinoma, Recurrent Ovarian Carcinoma, Recurrent Ovarian Carcinosarcoma, Recurrent Ovarian Clear Cell Adenocarcinoma, Recurrent Ovarian Endometrioid Adenocarcinoma, Recurrent Ovarian High Grade Serous Adenocarcinoma, Recurrent Primary Peritoneal Carcinoma, Recurrent Primary Peritoneal Clear Cell Adenocarcinoma, Recurrent Primary Peritoneal Endometrioid Adenocarcinoma, Recurrent Primary Peritoneal High Grade Serous Adenocarcinoma, Recurrent Primary Peritoneal Carcinosarcoma

Sponsor: Mayo Clinic

Locations: 3 active-listed locations

[177Lu]Lu-NeoB in Combination With Ribociclib and Fulvestrant in Participants With ER+, HER2- and GRPR+ Advanced Breast Cancer

Trial ID: NCT05870579   Registry: ClinicalTrials.gov

Intervention: [68Ga]Ga-NeoB, [177Lu]Lu-NeoB, Ribociclib, Fulvestrant, Goserelin

Condition: Breast Cancer

Sponsor: Novartis Pharmaceuticals

Locations: 13 active-listed locations

"Clinical Evaluation of Self-Assembling Peptides Versus Tri-Calcium Phosphate Based Varnish in Treatment of White Spot Lesions; Split-Mouth Randomized Clinical Trial"

Trial ID: NCT07289932   Registry: ClinicalTrials.gov

Intervention: Curodont Repair (SAP P11-4), Clinpro White Varnish (Tri-Calcium Phosphate, TCP)

Condition: White Spot Lesions

Sponsor: Ain Shams University

Locations: 1 active-listed location

A Phase 1b/2, Multi-center, Single Arm Study to Assess the Safety and Efficacy of Neoantigen Synthetic Long Peptide Vaccines in Patients With Local Or Metastatic Solid Tumors

Trial ID: NCT05741242   Registry: ClinicalTrials.gov

Intervention: Personalized Synthetic Long Peptide Vaccine

Condition: Cancer, Solid Tumor

Sponsor: Jaime Leandro Foundation for Therapeutic Cancer Vaccines

Locations: 6 active-listed locations

Assessing Remote Confirmation of Type 1 Diabetes

Trial ID: NCT06821360   Registry: ClinicalTrials.gov

Intervention: C-peptide test

Condition: Diabetes, Type 1 Diabetes (T1D)

Sponsor: Royal Devon and Exeter NHS Foundation Trust

Locations: 1 active-listed location

Can SAP P11-4 Affect The Appearance of Interproximal Cavities on an X-ray in a Military Population

Trial ID: NCT07829328   Registry: ClinicalTrials.gov

Intervention: 0.05% Sodium Fluoride with Self-Assembling Peptides

Condition: Incipient Interproximal Caries

Sponsor: Tripler Army Medical Center

Locations: 1 active-listed location

Clinical Study of 68Ga-labeled Novel Nectin-4 Bicyclic Peptide PET/CT for Imaging of Solid Tumors With High Nectin-4 Expression

Trial ID: NCT07319130   Registry: ClinicalTrials.gov

Intervention: Immunohistochemistry

Condition: Solid Tumors With High Expression of Nectin4

Sponsor: The First Affiliated Hospital of Soochow University

Locations: 1 active-listed location

Clinical Study of the Therapeutic Effectiveness of In-silico-Designed, Machine Learning Inspired, and Quantum-molecularly Coupled Personalized Neoantigenic Vaccines Microlyvaq™ in Patients With Advanced Non-small Cell Lung Cancer

Trial ID: NCT07285434   Registry: ClinicalTrials.gov

Intervention: Microlyvaq™ (Personalized Multi-Epitope Immunotherapeutic)

Condition: NSCLC (Non-small Cell Lung Cancer), Squamous Lung Cancer With FGFR1 Amplification, Non-Squamous Non Small Cell Lung Cancer

Sponsor: Biogenea Pharmaceuticals Ltd.

Locations: 1 active-listed location

Comparison of Neuromodulatory Treatment of Migraine Headache with Acupuncture and Transcranial Direct Current Stimulation

Trial ID: NCT06834022   Registry: ClinicalTrials.gov

Intervention: Transcranial direct current stimulation, Acupuncture

Condition: Migraine

Sponsor: University Medical Centre Ljubljana

Locations: 1 active-listed location

Disease Prevention in Clinical Practice Base on Patient Specific Physiology

Trial ID: NCT03308773   Registry: ClinicalTrials.gov

Intervention: Lifestyle modification in routine care of patients

Condition: PreDiabetes, Insulin Resistance, Type2 Diabetes, NASH - Nonalcoholic Steatohepatitis, Diastolic Dysfunction, Dementia, Atrial Fibrillation, Cancer, Atherosclerosis, Carotid Plaque

Sponsor: Pacific Coast Family Medical Group

ECG Low Ejection Fraction Detection and Guiding in AI Navigated Treatment Era

Trial ID: NCT06968533   Registry: ClinicalTrials.gov

Intervention: AI-ECG guided diagnosis

Condition: Heart Failure, Ventricular Dysfunction, Left, Artificial Intelligence, Early Diagnosis, Asymptomatic Diseases, Cost-Benefit Analysis

Sponsor: National Defense Medical Center, Taiwan

Locations: 1 active-listed location

Effect of Glucagon-like Peptide-1 (GLP-1) Receptor Agonist Stimulation on Smoking Consumption in Type 2 Diabetes Patients

Trial ID: NCT06924697   Registry: ClinicalTrials.gov

Intervention: Application of GLP-1RAs drugs, DPP-4i group

Condition: Diabetes Mellitus, Type 2, Nicotine Dependence, Cigarettes

Sponsor: Shanghai East Hospital

Locations: 1 active-listed location

Effects of Dried Whole Fruits on Metabolism in Diabetes

Trial ID: NCT07354386   Registry: ClinicalTrials.gov

Intervention: Freeze dried whole Saskatoon berry, Freeze dried apple slice bulk

Condition: Prediabetes, Type 2 Diabetes

Sponsor: University of Manitoba

Locations: 1 active-listed location

Enhancing the Natriuretic Peptide System in HFpEF

Trial ID: NCT05279742   Registry: ClinicalTrials.gov

Intervention: MANP, Sacubitril/Valsartan, Oral Placebo, Injection Placebo

Condition: Heart Failure With Preserved Ejection Fraction, Chronic Kidney Diseases

Sponsor: Horng Chen

Locations: 1 active-listed location

Evaluating Benefit of Peptide Based Diet in Obese HEN Patients

Trial ID: NCT05080699   Registry: ClinicalTrials.gov

Intervention: Peptamen Intense VHP, Nestlé Health Science, Switzerland

Condition: Obesity

Sponsor: Mayo Clinic

Locations: 1 active-listed location

GLP_1 RA Ultrasound Study

Trial ID: NCT06581120   Registry: ClinicalTrials.gov

Intervention: Glucagon-Like Peptide-1 receptor agonists, Point of Care Gastric Ultrasound

Condition: Glucagon Like Peptide-1 (GLP-1, Delayed Gastric Emptying, Risk of Aspiration, Diabetes, Morbid Obesity

Sponsor: Children's Hospital Medical Center, Cincinnati

Locations: 1 active-listed location

GYNORYLAQ™-VLINIVAL™: Ψ-Guided Personalized Neoantigen Peptide Vaccine for High-Risk Endometrial Cancer

Trial ID: NCT07316361   Registry: ClinicalTrials.gov

Intervention: • Biological: GYNORYLAQ-TM Personalized Neoantigenic Peptide Vaccine

Condition: Endometrial Carcinoma, Endometrial Carcinoma Stage III

Sponsor: Biogenea Pharmaceuticals Ltd.

Locations: 1 active-listed location

Influence of Specific Collagen Peptides on Training-Induced Metabolic and Biomechanical Adaptations of Skeletal Muscle

Trial ID: NCT06689761   Registry: ClinicalTrials.gov

Intervention: ColCT, ColET, PlaCT, PlaET

Condition: Collagen Supplementation

Sponsor: University of Vienna

Locations: 1 active-listed location

Pain Biomarker Study

Trial ID: NCT03511846   Registry: ClinicalTrials.gov

Intervention: Oral capsaicin, Topical capsaicin, Intranasal capsaicin, Cold Water Irrigation, Medical Air, Low Flow Oxygen, High Flow Oxygen

Condition: Migraine, Cluster Headache, Trigeminal Autonomic Cephalgia, Hemicrania Continua, Paroxysmal Hemicrania, SUNCT, Short-Lasting Unilateral Neuralgiform Headache With Conjunctival Injection and Tearing

Sponsor: The University of Texas Health Science Center, Houston

Locations: 1 active-listed location

Personalized Peptide Vaccine in Treating Patients With Advanced Pancreatic Cancer or Colorectal Cancer

Trial ID: NCT02600949   Registry: ClinicalTrials.gov

Intervention: Imiquimod, Pembrolizumab, Sotigalimab, Synthetic Tumor-Associated Peptide Vaccine Therapy, Computed Tomography, Magnetic Resonance Imaging

Condition: Metastatic Colorectal Adenocarcinoma, Metastatic Pancreatic Ductal Adenocarcinoma, Stage IV Colorectal Cancer AJCC v7, Stage IV Pancreatic Cancer AJCC v6 and v7, Stage IVA Colorectal Cancer AJCC v7, Stage IVB Colorectal Cancer AJCC v7

Sponsor: M.D. Anderson Cancer Center

Locations: 1 active-listed location

RegisterNET - A Registry for Neuroendocrine Tumors in the USA and Worldwide

Trial ID: NCT02270567   Registry: ClinicalTrials.gov

Intervention: NETest

Condition: Neuroendocrine Tumor, Carcinoid, Neuroendocrine Carcinoma

Sponsor: Wren Laboratories LLC

Locations: 1 active-listed location

Saskatoon Berry on Metabolism and Gut Microbiota in Healthy Subjects

Trial ID: NCT04809688   Registry: ClinicalTrials.gov

Intervention: Saskatoon berry, Dried Saskatoon berry

Condition: Nutritional and Metabolic Diseases

Sponsor: University of Manitoba

Locations: 1 active-listed location

The Antiemetic Effects of Increased Splanchnic Perfusion, Induced by the Gut Hormone GIP, in Healthy Individuals

Trial ID: NCT07687589   Registry: ClinicalTrials.gov

Intervention: Glucose-dependent Insulinotropic Polypeptide (GIP), GLP-1 (7-36) amide, Apomorphine Injectable Solution, Saline (0.9% NaCl)

Condition: Emesis

Sponsor: University of Copenhagen

Locations: 1 active-listed location

The Effects of Kefir on Pediatric Obesity

Trial ID: NCT06500104   Registry: ClinicalTrials.gov

Intervention: Kefir peptide, Placebo

Condition: Obesity

Sponsor: China Medical University Hospital

Locations: 1 active-listed location

Treatment of Atypical Resistant Facial Pain

Trial ID: NCT07250984   Registry: ClinicalTrials.gov

Intervention: intravenous administration of ACMP

Condition: Facial Pain

Sponsor: Alenka Spindler-Vesel

Locations: 1 active-listed location

Validation of the Snouda Metabolic Score for Phenotyping and Guiding Reversal in Type 2 Diabetes

Trial ID: NCT07606872   Registry: ClinicalTrials.gov

Intervention: Phenotype-Matched Dietary Protocol, Structured Progressive Exercise Protocol, Targeted Nutritional Supplementation, Structured Intermittent Fasting Protocol

Condition: Type 2 Diabetes Mellitus (T2DM), Insulin Resistance, Metabolic Syndrome

Sponsor: Salah Snouda

Locations: 1 active-listed location

Vicia Faba Peptides and Resistance Training in the Elderly

Trial ID: NCT07858292   Registry: ClinicalTrials.gov

Intervention: Vicia faba L.-derived peptides, Placebo, Supervised Resistance Training

Condition: Healthy Aging

Sponsor: Universidade Cesumar (UNICESUMAR)

Locations: 1 active-listed location

Whole Heart Radiotherapy for End-stage Heart Failure

Trial ID: NCT06299176   Registry: ClinicalTrials.gov

Intervention: Whole Heart Radiation Therapy

Condition: Heart Failure NYHA Class III, Heart Failure NYHA Class IV, End-stage Heart Failure, Heart Failure With Reduced Ejection Fraction

Sponsor: McGill University Health Centre/Research Institute of the McGill University Health Centre

Locations: 1 active-listed location

"Longitudinal Analysis of Amylin Levels in Migraine Patients Undergoing an Anti- CGRP/CGRPr Treatment"

Trial ID: NCT06692088   Registry: ClinicalTrials.gov

Condition: High Frequency Episodic Migraine and Chronic Migraine

Sponsor: Fundación Marques de Valdecilla

64Cu-GRIP B in Patients With Acute Myocarditis

Trial ID: NCT07481136   Registry: ClinicalTrials.gov

Intervention: 64Cu-GRIP B is a radiolabeled peptide tracer, a copper-64 isotope bound to a peptide designed to target extracellular Granzyme B

Condition: Acute Myocarditis

Sponsor: Javid Moslehi, MD

Locations: 1 active-listed location

A Clinical Study for the Efficacy and Safety of BL0020 Injection in Patients With Small Cell Lung Cancer Transformed From Non-Small Cell Lung Cancer Following EGFR TKI Therapy

Trial ID: NCT07414927   Registry: ClinicalTrials.gov

Intervention: BL0020

Condition: Small Cell Carcinoma of Lung

Sponsor: Shanghai Best-Link Bioscience, LLC

Locations: 1 active-listed location

A Clinical Trial of Rimegepant for Vestibular Migraine Evaluation: Pre-experiment

Trial ID: NCT06748664   Registry: ClinicalTrials.gov

Intervention: Rimegepant, Placebo

Condition: Vestibular Migraine, Adults 18 Years and Older (no Other Exclusion Criteria)

Sponsor: Second Affiliated Hospital, Zhejiang University, School of Medicine

A Multicenter Clinical Study on Protein Absorption Efficiency in Patients With Pancreatic Exocrine Insufficiency in the ICU

Trial ID: NCT07709611   Registry: ClinicalTrials.gov

Intervention: Short peptide, Protein

Condition: High-risk Patients With Pancreatic Exocrine Insufficiency, Enteral Nutrition Feeding

Sponsor: Shanghai 10th People's Hospital

Locations: 1 active-listed location

A Novel Proline-rich Peptide Hydrogel for Periodontal Regeneration in Adult Periodontitis Patients

Trial ID: NCT07581613   Registry: ClinicalTrials.gov

Intervention: Hydrogel

Condition: Periodontal Disease, Intrabony Periodontal Defects

Sponsor: Siddharth Shanbhag

Locations: 2 active-listed locations

A Phase 1/2 Study of CBX-12 in Children, Adolescents, or Young Adults With Solid Tumors That Have Come Back After Treatment or Are Difficult to Treat

Trial ID: NCT07830667   Registry: ClinicalTrials.gov

Intervention: Archive Sample Retrieval, Biospecimen Collection, pH Low Insertion Peptide-exatecan Conjugate CBX-12, Radiologic Imaging Procedure

Condition: Recurrent Childhood Ewing Sarcoma, Recurrent Childhood Malignant Solid Neoplasm, Recurrent Childhood Rhabdomyosarcoma, Recurrent Ewing Sarcoma, Recurrent Extracranial Malignant Solid Neoplasm, Recurrent Rhabdomyosarcoma, Refractory Childhood Ewing Sarcoma, Refractory Childhood Malignant Solid Neoplasm, Refractory Childhood Rhabdomyosarcoma, Refractory Ewing Sarcoma, Refractory Extracranial Malignant Solid Neoplasm, Refractory Rhabdomyosarcoma

Sponsor: Children's Oncology Group

A Phase I Study of PepGNP-ChikV in Healthy Volunteers

Trial ID: NCT07394426   Registry: ClinicalTrials.gov

Intervention: PepGNP-ChikV, Placebo

Condition: Chikungunya, Chikungunya Fever, Chikungunya Virus Infection, Chikungunya Virus Infections, Chikungunya Virus

Sponsor: Gylden Pharma Ltd

A Randomized Controlled Trial of Acupuncture for the Management of Hot Flashes in Patients With Hormone Receptor-Positive Breast Cancer

Trial ID: NCT07294339   Registry: ClinicalTrials.gov

Intervention: True Acupuncture, Sham Acupuncture

Condition: Acupuncture Treatment, Hormone Receptor-Positive Breast Cancer, Hot Flashes

Sponsor: Peking University People's Hospital

Locations: 1 active-listed location

A Research Study to Evaluate BLX-7006 in Healthy Adults

Trial ID: NCT07140055   Registry: ClinicalTrials.gov

Intervention: BLX-7006, Placebo

Condition: Normal Healthy Volunteer, Safety After Oral Intake

Sponsor: Biolexis Therapeutics

Locations: 1 active-listed location

A Single Arm Clinical Study of Dendritic Cell Vaccine Loaded With Circular RNA Encoding Cryptic Peptide for Patients With HER2-negative Advanced Breast Cancer

Trial ID: NCT06530082   Registry: ClinicalTrials.gov

Intervention: CircFam53B-219aa DC vaccine, camrelizumab

Condition: Breast Neoplasms

Sponsor: Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

A Study of Weight Loss Intervention With Tirzepatide and Progestin Intrauterine Device to Treat Endometrial Hyperplasia and Grade 1 Endometrial Cancer

Trial ID: NCT07349641   Registry: ClinicalTrials.gov

Intervention: Medical Device Usage and Evaluation, Tirzepatide

Condition: Endometrial Atypical Hyperplasia/Endometrioid Intraepithelial Neoplasia, FIGO Grade 1 Endometrial Endometrioid Adenocarcinoma

Sponsor: National Cancer Institute (NCI)

Locations: 3 active-listed locations

A Two-part Study of Lembas Edge Evaluating Tolerability and Postprandial Glycemic Control

Trial ID: NCT07711288   Registry: ClinicalTrials.gov

Intervention: Low dose alpha-galactosidase-derived peptide, Medium dose alpha-galactosidase-derived peptide, High dose alpha-galactosidase-derived peptide, Placebo

Condition: Postprandial Glycemic Control, Prediabetic Overweight and Obese Adults

Sponsor: Lembas

Locations: 1 active-listed location

AQT90 FLEX NTproBNP (N-terminal Pro-brain Natriuretic Peptide) 2 Test Kit - Clinical Evaluation Study Protocol - China

Trial ID: NCT07208877   Registry: ClinicalTrials.gov

Condition: Diagnostic Tests

Sponsor: Radiometer Medical ApS

AQT90 FLEX NTproBNP (N-terminal Pro-brain Natriuretic Peptide) 2 Test Kit - Reference Interval Study Protocol - China

Trial ID: NCT06963619   Registry: ClinicalTrials.gov

Condition: Diagnostic Tests

Sponsor: Radiometer Medical ApS

Allogeneic B7H3 CAR-γδT Cell Therapy for Advanced Solid Tumors

Trial ID: NCT06825455   Registry: ClinicalTrials.gov

Intervention: Fludarabine, Cyclophosphamide, B7H3 CAR-γδT cells

Condition: Advanced Solid Tumors, Ovarian Cancers, Peritoneal (metastatic) Cancer

Sponsor: Peking University

Locations: 1 active-listed location

Alterations of the Renin-angiotensin-aldosterone System in sEptic Shock

Trial ID: NCT07721974   Registry: ClinicalTrials.gov

Intervention: Collection of fluid samples

Condition: Septic Shock

Sponsor: Assistance Publique - Hôpitaux de Paris

Amylin-Induced Migraine Attacks Without Aura

Trial ID: NCT07340788   Registry: ClinicalTrials.gov

Intervention: Amylin, Placebo

Condition: Headache Disorders, Primary, Headache Disorders, Brain Diseases, Nervous System Diseases, Central Nervous System Diseases, Neurologic Manifestations, Signs and Symptoms, Pathological Conditions, Signs and Symptoms, Migraine Disorders, Headache, Pain, Peptide Hormones, Hormones, Hormones, Hormone Substitutes, and Hormone Antagonists, Peptides, Amino Acids, Peptides, and Proteins, Amylin, Pramlintide

Sponsor: Danish Headache Center

Locations: 1 active-listed location

An AI-ECG-Based Approach for Dynamic Assessment of Heart Failure Risk and Myocardial Recovery Following Atrial Fibrillation Ablation

Trial ID: NCT07708818   Registry: ClinicalTrials.gov

Condition: Atrial Fibrillation (AF), Heart Failure With Mildly Reduced Ejection Fraction (HFmrEF)

Sponsor: Ewha Womans University Mokdong Hospital

Locations: 1 active-listed location

Anti-citrullinated SR-A Peptide (Anti-csp) Antibody as a Biomarker in Rheumatoid Arthritis (RA).

Trial ID: NCT07147127   Registry: ClinicalTrials.gov

Condition: Rheumatoid Arthritis (RA)

Sponsor: Walaa sharif Eid Ahmed

Assessment of the Adherence to a Gluten-free Diet and Nutritional Status of Paediatric Patients With Coeliac Disease

Trial ID: NCT07157137   Registry: ClinicalTrials.gov

Condition: Celiac Disease in Children, Gluten-free Diet

Sponsor: Medical University of Warsaw

Autologous CD6-CAR Treg Cells for Patients With Stage 3 Type 1 Diabetes

Trial ID: NCT07395050   Registry: ClinicalTrials.gov

Intervention: AutoCD6-CAR Treg cells

Condition: Stage 3 Type 1 Diabetes

Sponsor: City of Hope Medical Center

Locations: 1 active-listed location

Autologous T Cells Targeting HPV16 HPV18 & Survivin in Patients With R/R HPV-related Oropharyngeal Cancers

Trial ID: NCT05582590   Registry: ClinicalTrials.gov

Intervention: Fludarabine, Cyclophosphamide, NEXI-003 T cells

Condition: Oropharyngeal Cancer, Human Papilloma Virus, Head and Neck Cancer, Head and Neck Squamous Cell Carcinoma, Oropharyngeal Squamous Cell Carcinoma, Oropharyngeal Cancer, Metastatic, Head and Neck Cancer Metastatic, HPV-Related Squamous Cell Carcinoma, HPV-Related Mucosal Head and Neck Squamous Cell Carcinoma, Relapsed Oropharyngeal SCC, Refractory Oropharyngeal Squamous Cell Carcinoma

Sponsor: NexImmune Inc.

Biomarker Panel Development for Early Identification of Worsening Heart Failure and Improved Post-acute Care

Trial ID: NCT07838766   Registry: ClinicalTrials.gov

Condition: Outpatients With Chronic Heart Failure, Heart Failure Chronic

Sponsor: Chang Gung Memorial Hospital

Biomarker Testing to Predict Radiation-Related Heart Disease in Lung Cancer Patients

Trial ID: NCT07869329   Registry: ClinicalTrials.gov

Intervention: Serum Pro-N-Cadherin Biomarker Assessment, Echocardiogram

Condition: Non-Small Cell Lung Cancer, Radiation-Induced Cardiac Disease

Sponsor: Duke University

Locations: 1 active-listed location

Blood Flow Restriction Combined With Aerobic or Resistance Exercise in Heart Failure

Trial ID: NCT07627737   Registry: ClinicalTrials.gov

Intervention: Aerobic Exercise Plus Blood Flow Restriction Resistance Training, Resistance Training Plus Blood Flow Restriction Aerobic Exercise

Condition: Heart Failure

Sponsor: Biruni University

Locations: 1 active-listed location

Brain Plasticity and GLP-1 Receptor Agonist Treatment for Obesity

Trial ID: NCT07021937   Registry: ClinicalTrials.gov

Intervention: Semaglutide 1.7mg subcutaneous, Placebo

Condition: Obesity/Therapy

Sponsor: University of Colorado, Denver

Locations: 1 active-listed location

CD147 Targeting Peptide Probe for PET Imaging in Solid Tumors

Trial ID: NCT06720298   Registry: ClinicalTrials.gov

Intervention: 18F-FDG

Condition: Solid Tumor

Sponsor: Peking University Cancer Hospital & Institute

Locations: 1 active-listed location

CIMAvax-EGF With KRAS G12C Inhibitor for the Treatment of Advanced, KRAS G12C Mutated Non Small Cell Lung Cancer

Trial ID: NCT07543172   Registry: ClinicalTrials.gov

Intervention: Adagrasib, Biospecimen Collection, Computed Tomography, Magnetic Resonance Imaging, Recombinant Human EGF-rP64K/Montanide ISA 51 Vaccine, Sotorasib

Condition: Advanced Lung Non-Small Cell Carcinoma, Stage III Lung Cancer AJCC v8, Stage IV Lung Cancer AJCC v8

Sponsor: Roswell Park Cancer Institute

Locations: 1 active-listed location

Calcitonin Gene-related Peptide Antibody in Acute Mountain Sickness

Trial ID: NCT07653516   Registry: ClinicalTrials.gov

Intervention: Fremanezumab 225 Mg/1.5 mL Subcutaneous Solution, Placebo

Condition: Acute Mountain Sickness

Sponsor: Insel Gruppe AG, University Hospital Bern

Locations: 1 active-listed location

Cardiac Biomarkers in Patients Receiving Immune Checkpoint Inhibitors (PRIME-ICI)

Trial ID: NCT07864727   Registry: ClinicalTrials.gov

Condition: Cardiotoxicity, Cardiac Biomarkers, Cancer

Sponsor: South Tees Hospitals NHS Foundation Trust

Locations: 1 active-listed location

Chinese, Overweight or Obesity, Real-World Registry Study

Trial ID: NCT07525037   Registry: ClinicalTrials.gov

Condition: Obesity Type 2 Diabetes Mellitus

Sponsor: Chinese PLA General Hospital

Locations: 1 active-listed location

Clinical Performance and Remineralization Potential of Self- Assembling Peptide P11-4 Containing Fluoride Versus Er, Cr: YSGG Laser Treatment and Micro Tensile Bond Strength of Giomer Restoration in Carious Lesions

Trial ID: NCT07065305   Registry: ClinicalTrials.gov

Intervention: Curodont Repair Fluoride Plus (Self-assembling peptide remineralization agent)P11-4 peptide, fluoride, mild acidic buffer (pH ~4.5) , Credentis AG, Switzerland, Beautifil II LS

Condition: Remineralization Potential, Dentin Caries

Sponsor: Al-Azhar University

Clinical Study of 68Ga-DOTA-BLP PET Imaging in Noninvasive Diagnosis of Malignant Tumors

Trial ID: NCT07459192   Registry: ClinicalTrials.gov

Condition: Canser

Sponsor: Daping Hospital and the Research Institute of Surgery of the Third Military Medical University

Locations: 1 active-listed location

Clinical Study of Active Intervention in High-risk HFpEF Patients

Trial ID: NCT06532019   Registry: ClinicalTrials.gov

Intervention: Targeted intervention based on risk factors

Condition: Heart Failure With Preserved Ejection Fraction

Sponsor: Xiangtan Central Hospital

Combination Therapy for Alcohol Use Disorder

Trial ID: NCT07249554   Registry: ClinicalTrials.gov

Intervention: Placebo, Glucagon-Like Peptide-1 Agonist (GLP-1), Naltrexone (oral tablets)

Condition: Alcohol Use Disorder

Sponsor: Johns Hopkins University

Locations: 1 active-listed location

Comparing Migraine Preventive Therapies vs. Anti-CGRP Therapies for Tinnitus in Patients With Migraine (COMPACT-PM)

Trial ID: NCT07655440   Registry: ClinicalTrials.gov

Intervention: Galcanezumab, Erenumab 70 mg, Eptinezumab, Atogepant, Amitriptyline, Nortriptyline, propranolol, Verapamil SR 120 mg, Candesartan, topiramate

Condition: Migraine Associated Vertigo, Tinnitus, Migraine, Vestibular Migraine

Sponsor: Stanford University

Comparison of Short Peptide and Whole Protein Formula in the Early Enteral Nutrition of Patients With Sepsis

Trial ID: NCT07038057   Registry: ClinicalTrials.gov

Intervention: Short peptide enteral nutrition, Whole protein enteral nutrition

Condition: Sepsis, Nutrition

Sponsor: Shanghai Zhongshan Hospital

Data-Driven Phenotyping in Heart Failure With Preserved Ejection Fraction

Trial ID: NCT07429396   Registry: ClinicalTrials.gov

Condition: Heart Failure, Heart Failure, Diastolic, Heart Failure With Preserved Ejection Fraction (HFPEF)

Sponsor: Instituto Politécnico de Leiria

Locations: 2 active-listed locations

Decision Support System for Diagnosis and Progression of Heart Failure

Trial ID: NCT06377319   Registry: ClinicalTrials.gov

Intervention: Cardiac Output Response to Stress (CORS) test

Condition: Heart Failure

Sponsor: Coventry University

Early Gliflozin for Elderly Patients With Acute Decompensated Heart Failure in the Emergency Department

Trial ID: NCT07392788   Registry: ClinicalTrials.gov

Intervention: Early initiation of dapagliflozin 10mg daily within 24h of emergency department admission, Telephone follow-up by cardiac nurse practitioner at 1 month, Standard acute decompensated heart failure care

Condition: Acute Heart Failure (AHF)

Sponsor: Centre Hospitalier Universitaire de Besancon

Eary Infusion of Eptinezumab for TreatmEnt of ACute Post-Traumatic Headaches (ELITE-ACT)

Trial ID: NCT07191145   Registry: ClinicalTrials.gov

Intervention: Eptinezumab, Placebo

Condition: Post Traumatic Headache

Sponsor: Sunnybrook Health Sciences Centre

Locations: 1 active-listed location

Effect of Add-on SGLT2i, TZD, or Combination Therapy in Type 2 Diabetes Patients on DPP4 Inhibitors

Trial ID: NCT07108985   Registry: ClinicalTrials.gov

Intervention: Sitagliptin 100 mg, Sitagliptin 100 mg + Dapagliflozin 10 mg, Sitagliptin 100 mg + Dapagliflozin 10 mg + Lobeglitazone 0.5 mg

Condition: Diabetes Mellitus, Type 2, Hyperglycemia, Insulin Resistance

Sponsor: Yonsei University

Locations: 1 active-listed location

Effect of Atogepant on the Vestibulo-Ocular Reflex in Healthy Adults and Adults With Migraine

Trial ID: NCT07826910   Registry: ClinicalTrials.gov

Intervention: Atogepant 60 mg, Placebo

Condition: Migraine Disorders, Brain, Healthy Adult Participants, Vestibulo-Ocular Reflex

Sponsor: Konrad Peter Weber

Locations: 1 active-listed location

Effect of CSIR-Developed High-Protein, Low-Glycaemic Index Rice on Glycaemic Response in Individuals With Prediabetes

Trial ID: NCT07762768   Registry: ClinicalTrials.gov

Intervention: Intervention Group

Condition: Prediabetes

Sponsor: Diabetes Foundation, India

Locations: 1 active-listed location

Effect of Early Time-Restricted Eating on Appetite, Appetite-Regulatory Hormones and Energy Intake

Trial ID: NCT07500792   Registry: ClinicalTrials.gov

Intervention: Normal diet, early Time-Restricted Eating (eTRE), instantaneous visual analogue scale (iVAS)

Condition: Healthy Adult Male

Sponsor: University of Glasgow

Locations: 1 active-listed location

Effect of Transcutaneous Electrical Acupoint Stimulation on Dyspareunia

Trial ID: NCT06730776   Registry: ClinicalTrials.gov

Intervention: Topical medication, Transcutaneous electrical acupoint stimulation

Condition: Dyspareunia (Female)

Sponsor: Cairo University

Locations: 1 active-listed location

Effects of Different Collagen Formulations on Knee Osteoarthritis

Trial ID: NCT07800780   Registry: ClinicalTrials.gov

Intervention: 10g Hydrolyzed Collagen, 5g Bioactive Collagen Peptide, Placebo (Maltodextrin)

Condition: Osteoarthritis, Knee

Sponsor: Cihangir Türemiş

Locations: 1 active-listed location

Effects of GLP-1 Receptor Agonists on Saliva and Oral Health

Trial ID: NCT07818226   Registry: ClinicalTrials.gov

Intervention: GLP-1 Receptor Agonists

Condition: Type 2 Diabetes, Obesity & Overweight, Xerostomia, Dental Caries

Sponsor: Kırıkkale University

Locations: 1 active-listed location

Effects of Selected Statins on Blood Glucose Levels in Healthy Volunteers

Trial ID: NCT07378293   Registry: ClinicalTrials.gov

Intervention: Simvastatin (10mg, 20mg, 40mg), Rosuvastatin (5mg, 20mg, 40mg), Atorvastatin (10mg, 20mg, 40mg)

Condition: Diabete Mellitus, Lipid Profile

Sponsor: Shaheed Benazir Bhutto University Sheringal Dir Upper

Locations: 2 active-listed locations

Efficacy and Safety of Rimegepant for Acute Dizziness

Trial ID: NCT07435090   Registry: ClinicalTrials.gov

Intervention: Rimegepant 75mg Orally Disintegrating Tablets (ODT), Betahistine Mesylate tablet

Condition: Dizziness

Sponsor: Shi Tianming

Efficacy and Safety of Tirzepatide (Spartina) in Chronic Kidney Failure

Trial ID: NCT07176663   Registry: ClinicalTrials.gov

Intervention: Tirzepatide

Condition: Obesity

Sponsor: Shahid Beheshti University of Medical Sciences

Locations: 1 active-listed location

Efficacy of Collagendep in Reducing Vulvar Dryness in Patients With Lichen Sclerosus Treated With Fat Grafting

Trial ID: NCT07450625   Registry: ClinicalTrials.gov

Intervention: Autologous Fat Grafting (Lipofilling), Collagendep Pink Beauty

Condition: Vulvar Lichen Sclerosus, Vulvar Atrophy

Sponsor: San Gallicano Dermatological Institute IRCCS

Efficacy of Ultrasound-Guided Combined Greater Occipital Nerve Block and Greater Auricular Nerve Block Versus Greater Occipital Nerve Block Alone in the Management of Chronic Migraine

Trial ID: NCT07763678   Registry: ClinicalTrials.gov

Intervention: greater occipital nerve block, Greater Auricular Nerve Block

Condition: Chronic Migraine Headache

Sponsor: Assiut University

Evaluation of 25(OH)D3 and LL-37 Levels in Periimplant Sulcus Fluid

Trial ID: NCT07280754   Registry: ClinicalTrials.gov

Condition: Peri Implantitis, Peri Implant Mucositis

Sponsor: Recep Tayyip Erdogan University

Evaluation of Cardiac and Endothelial Function in Children and Adolescents Treated With Anthracycline

Trial ID: NCT07253077   Registry: ClinicalTrials.gov

Intervention: Biomarker detection

Condition: Anthracycline Related Cardiotoxicity in Childhood Cancers, Chemotherapeutic Toxicity, Childhood Cancer Survivors

Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Locations: 1 active-listed location

Evaluation of SPM™ Topical Cosmetic Application on Skin Appearance, Hydration, and Barrier Support in Healthy Adults

Trial ID: NCT07236736   Registry: ClinicalTrials.gov

Intervention: Skin biopsy, Corneometer® Measurement, Tewameter® Measurement

Condition: Healthy Skin, Skin Hydration

Sponsor: Biocoz Global Pte. Ltd.

Locations: 1 active-listed location

Evaluation of Serum Preptin Levels in Patients With Polycystic Ovary Syndrome

Trial ID: NCT07736079   Registry: ClinicalTrials.gov

Condition: Polycystic Ovary Syndrome (PCOS), Insulin Resistance

Sponsor: GÜLDEN ANATACA

Evaluation of the Efficacy of rhBNP in Patients With Diuretic Resistance After Cardiac Surgery

Trial ID: NCT07086287   Registry: ClinicalTrials.gov

Intervention: rhBNP and standard basic treatment

Condition: After Cardiac Surgery, Diuretic Resistance

Sponsor: The First Affiliated Hospital of Anhui Medical University

Locations: 1 active-listed location

Evaluation of the Role of Brain Natriuretic Peptide in Acute Coronary Syndrome .

Trial ID: NCT06734416   Registry: ClinicalTrials.gov

Condition: Acute Coronary Syndromes

Sponsor: Assiut University

Evolution of the Cognitive Profile and Quality of Life of Adult Patients Suffering From Severe Migraines Under Preventive Treatment

Trial ID: NCT07691164   Registry: ClinicalTrials.gov

Intervention: Cognitive assessment mapping

Condition: Chronic Migraine

Sponsor: University Hospital, Strasbourg, France

Locations: 1 active-listed location

Exploratory Study of the Effects of Peptide PMS-001 on Long-Delay Recall in Patients With Moderate to Severe Dementia

Trial ID: NCT06946511   Registry: ClinicalTrials.gov

Intervention: Peptide PMS-001 Intravenous Injection, Placebo

Condition: Dementia

Sponsor: Ruijin Hospital

Locations: 2 active-listed locations

Explore the Effect of Bitter Melon Peptides on Glycemic Control and Metabolic Indicators in Diabetic Patients

Trial ID: NCT06970834   Registry: ClinicalTrials.gov

Intervention: bitter melon peptides

Condition: Diabetes

Sponsor: Changhua Christian Hospital

Exploring the Influence of Glucagon-like Peptide -1 (GLP-1) Medications on Food Cravings, Food Selection, and Food Intake Following Exposure to Food Advertisements

Trial ID: NCT07505134   Registry: ClinicalTrials.gov

Intervention: Food advertisements, Tech advertisements

Condition: GLP - 1

Sponsor: Penn State University

Flow Cytometric Immune Monitoring of B. Afzelii-Specific T Lymphocytes

Trial ID: NCT07703787   Registry: ClinicalTrials.gov

Condition: Lyme Borreliosis, Lyme Disease

Sponsor: University Hospital, Strasbourg, France

Locations: 1 active-listed location

Functional Milk Supplementation to Reduce In-Stent Restenosis in STEMI Patients (SMASOEA Trial)

Trial ID: NCT07176104   Registry: ClinicalTrials.gov

Intervention: Functional Bovine Milk, Non-Functional Bovine Milk

Condition: ST-elevation Myocardial Infarction (STEMI), In-stent Restenosis

Sponsor: Raffaele Marfella

Locations: 1 active-listed location

GLP-1 Agonists for Lung Function Improvement and Muscle Restoration in COPD

Trial ID: NCT07747805   Registry: ClinicalTrials.gov

Intervention: Tirzepatide

Condition: COPD, Obesity & Overweight, Sarcopenia

Sponsor: The Cleveland Clinic

Locations: 1 active-listed location

GLP-1 RA for Stage 1 Type 1 Diabetes

Trial ID: NCT07430332   Registry: ClinicalTrials.gov

Intervention: Semaglutide, Placebo

Condition: Stage 1 Diabetes Mellitus, Type 1

Sponsor: Children's Hospital Medical Center, Cincinnati

Locations: 1 active-listed location

GLP-1/GIP Receptor Agonists in Obesity-Related HFpEF: The GLIDE-HF Registry

Trial ID: NCT07787936   Registry: ClinicalTrials.gov

Intervention: GLP-1 / GIP receptor agonist

Condition: Heart Failure With Preserved Ejection Fraction, Obesity, Diastolic Heart Failure, Pulmonary Hypertension, Iron Deficiency

Sponsor: Miedziowe Centrum Zdrowia SA

Locations: 1 active-listed location

Gastrointestinal Hormones and Metabolomic Profiling Following Mixed-Meal Tolerance Tests in Patients at Risk of Refeeding Syndrome

Trial ID: NCT07674589   Registry: ClinicalTrials.gov

Condition: Refeeding Syndrome, Malnutrition

Sponsor: Hospital Garcia de Orta

Locations: 1 active-listed location

Genetic Architecture of Natriuretic Peptides and Blood Pressure Response

Trial ID: NCT07118592   Registry: ClinicalTrials.gov

Intervention: Low Salt Diet, High Salt Diet, Saline Infusion

Condition: Hypertension (HTN), Cardiometabolic Diseases

Sponsor: University of Alabama at Birmingham

Locations: 1 active-listed location

Glucagon-like Peptide 1 Receptor Agonist in Acute Large Vessel Occlusion Stroke After Endovascular Treatment

Trial ID: NCT06788626   Registry: ClinicalTrials.gov

Intervention: Semaglutide 0.5 mg, Standard medical treatment

Condition: Acute Ischemic Stroke, Large Vessel Occlusion, Neuroprotective Drugs, Endovascular Treatment

Sponsor: Wei Hu

Locations: 1 active-listed location

Glucagon-like Peptide 2 (GLP-2) in Undernourished Women Improving From Histology-Confirmed Environmental Enteric Dysfunction (EED)

Trial ID: NCT07537686   Registry: ClinicalTrials.gov

Intervention: Teduglutide 0.05 dose

Condition: Environmental Enteric Dysfunction

Sponsor: International Centre for Diarrhoeal Disease Research, Bangladesh

Glucose Levels in Acute Pancreatitis and the Impact of Insulin Depletion and Bacterial Endotoxaemia

Trial ID: NCT06972238   Registry: ClinicalTrials.gov

Condition: Pancreatitis, Acute, Hyperglycaemia

Sponsor: Manchester University NHS Foundation Trust

Henagliflozin's Impact on Prediabetes Remission

Trial ID: NCT06448130   Registry: ClinicalTrials.gov

Intervention: Henagliflozin 5mg, Henagliflozin 10mg, Placebo

Condition: PreDiabetes, Prediabetic State, Type 2 Diabetes, Glucose Metabolism Disorders

Sponsor: Shandong Provincial Hospital

Locations: 50 active-listed locations

High-Protein Diet for Improving Alcoholic Fatty Liver Disease

Trial ID: NCT07632222   Registry: ClinicalTrials.gov

Intervention: high protein diet, control diet, perilla peptide dietary group

Condition: Alcohol-associated Fatty Liver Disease

Sponsor: Li Lab,MD

High-protein plUs reSistance Training in gLucagon-like pEptide 1 Receptor Agonist Users (HUSTLE)

Trial ID: NCT07700030   Registry: ClinicalTrials.gov

Intervention: High protein diet, Resistance Training (RT) Programs

Condition: Weight Loss

Sponsor: NYU Langone Health

Locations: 1 active-listed location

Hypersensitivity to Amylin in Post-Traumatic Headache

Trial ID: NCT07340775   Registry: ClinicalTrials.gov

Intervention: Amylin, Placebo

Condition: Headache Disorders, Secondary, Brain Diseases, Headache Disorders, Nervous System Diseases, Central Nervous System Diseases, Neurologic Manifestations, Signs and Symptoms, Pathological Conditions, Signs and Symptoms, Post-Traumatic Headache, Pain, Peptide Hormones, Hormones, Hormones, Hormone Substitutes, and Hormone Antagonists, Peptides, Amino Acids, Peptides, and Proteins, Amylin, Pramlintide

Sponsor: Danish Headache Center

Locations: 1 active-listed location

Hypothalamic GLP-1 Response in Healthy Weight and Obesity

Trial ID: NCT07854886   Registry: ClinicalTrials.gov

Intervention: Gastric glucose, GLP-1(7-36)NH2, Exendin(9-39)NH2, Isoglycemic intravenous glucose infusion

Condition: Obesity, Normal Weight, Glucose Intolerance

Sponsor: University of Copenhagen

Locations: 1 active-listed location

Impact of BPC-157 on Recovery Following Rotator Cuff Repair Surgery

Trial ID: NCT07803250   Registry: ClinicalTrials.gov

Intervention: BPC-157, Sham (No Treatment)

Condition: Rotator Cuff Tear

Sponsor: University of Arkansas

Locations: 1 active-listed location

Impact of Oral Supplementation With Bioactive Collagen Peptides and Other Functional Ingredients

Trial ID: NCT07151482   Registry: ClinicalTrials.gov

Intervention: Collagendep

Condition: Genitourinary Syndrome of Menopause

Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Individualized Location-based rTMS for Migraine Treatment: A Multicenter Clinical Study

Trial ID: NCT07086274   Registry: ClinicalTrials.gov

Intervention: Individualized location-based Repetitive Transcranial Magnetic Stimulation, Traditional location-based Repetitive Transcranial Magnetic Stimulation

Condition: Migraine, Transcranial Magnetic Stimulation Repetitive

Sponsor: First Affiliated Hospital of Zhejiang University

Locations: 1 active-listed location

Induction of Migraine Attacks With Aura Using Pituitary Adenylate Cyclase Activating Polypeptide-38

Trial ID: NCT07342296   Registry: ClinicalTrials.gov

Intervention: Pituitary Adenylate Cyclase Activating Polypeptide-38 (PACAP-38), Placebo

Condition: Migraine With Aura, Migraine Aura

Sponsor: Danish Headache Center

Integrating Tumor Genomics and Urinary Exosomal Proteomics to Establish a Multi-Layer Biomarker Framework for Early Risk Stratification and Post-Treatment Surveillance in Fresh Thyroid Cancer Patients

Trial ID: NCT07532356   Registry: ClinicalTrials.gov

Condition: Genomics, Thyroid Cancer, NGS

Sponsor: National Taiwan University Hospital

Interest of Urinary Measurement of Immunogenic Gluten Peptides (GIP) in the Follow-up of Pediatric Celiac Patients.

Trial ID: NCT07578038   Registry: ClinicalTrials.gov

Intervention: Urinary measurement of GIP, Usual follow-up and measurement of urinary GIP.

Condition: Coeliac Disease

Sponsor: Fondation Lenval

Locations: 1 active-listed location

Italian Multicenter Experience With Radioreceptor-assisted Therapy (PRRT)

Trial ID: NCT07538791   Registry: ClinicalTrials.gov

Intervention: Peptide Receptor Radionuclide Therapy (PRRT)

Condition: Pheochromocytomas, Paragangliomas

Sponsor: Azienda USL Reggio Emilia - IRCCS

Locations: 10 active-listed locations

Low-FODMAP Diet and Intestinal Permeability in Patients With Irritable Bowel Syndrome

Trial ID: NCT07467278   Registry: ClinicalTrials.gov

Intervention: low fodmap diet, dietary intervention

Condition: Irritable Bowel Syndrome

Sponsor: Istanbul Medipol University Hospital

Maternal Outcomes With Methamphetamine Use and Cardiac Assessment for Rural Dissemination (MOM CARD)

Trial ID: NCT07309757   Registry: ClinicalTrials.gov

Condition: Methamphetamine Abuse

Sponsor: Oregon Health and Science University

Mesenchymal Stromal/Stem Cells-Derived Exosomes (MSC-Exos) Therapy for Type 2 Diabetes Mellitus Patients

Trial ID: NCT07144241   Registry: ClinicalTrials.gov

Intervention: Mesenchymal Stromal/Stem Cells-Derived Exosomes (Exo-HWS + 1 vial Exo-HUVEC) Therapy, Mesenchymal Stromal/Stem Cells-Derived Exosomes (Exo-HWS ) Therapy

Condition: Type 2 Diabetes Mellitus

Sponsor: Universitas Indonesia

Locations: 1 active-listed location

Migraine and Endometriosis: The FEMININE Study

Trial ID: NCT07519343   Registry: ClinicalTrials.gov

Condition: Migraine, Endometriosis

Sponsor: Hospital Universitari Vall d'Hebron Research Institute

Locations: 1 active-listed location

Multi-peptide Vaccination Adjuvanted With XS15 in Acute Myeloid Leukemia Patients

Trial ID: NCT06252584   Registry: ClinicalTrials.gov

Intervention: Vaccines, Peptide

Condition: Acute Myeloid Leukemia, Adult

Sponsor: University Hospital Tuebingen

Neoantigen Peptide Vaccine Plus Pembrolizumab in Renal Cell Carcinoma

Trial ID: NCT07686744   Registry: ClinicalTrials.gov

Intervention: Personalized Neoantigen Polyepitope Peptide Vaccine

Condition: Renal Cell Carcinoma, Advanced, Recurrent, Refractory

Sponsor: Jian Lin

Locations: 1 active-listed location

Oncological Prognosis of Prostate Lesions by Chemical Exchange Saturation Transfer Magnetic Resonance Imaging (CEST-MRI)

Trial ID: NCT06669273   Registry: ClinicalTrials.gov

Intervention: CEST MRI sequence at 3T

Condition: Suspected Prostate Cancer (increased PSA Level)

Sponsor: University Hospital, Clermont-Ferrand

Locations: 1 active-listed location

Optimization of Heart Failure (HF) Medical Therapy After Transcatheter Valve Intervention (TVI) in Patients With Heart Failure With Reduced Ejection Fraction (HFrEF)

Trial ID: NCT06667128   Registry: ClinicalTrials.gov

Intervention: Rapid Uptitration of Guideline-Directed Medical Therapy, Elecsys® NT-proBNP - Roche Diagnostics, Rapid Up-Titration GDMT Group with Hospital Monitoring

Condition: Heart Failure, Valvulopathy, Aortic Stenosis, Aortic Regurgitation Disease, Mitral Regurgitation, Tricuspid Regurgitation, Brain Natriuretic Peptide, Mitraclip, TAVI(Transcatheter Aortic Valve Implantation)

Sponsor: IRCCS Ospedale San Raffaele

Locations: 1 active-listed location

PD-L1 Targeting Peptide Probe for PET Imaging of Solid Tumor

Trial ID: NCT07442292   Registry: ClinicalTrials.gov

Condition: Lung Cancer (NSCLC), Lung Cancer (SCLC), Melanoma (Skin Cancer), Melanoma Metastatic, PD-L1, PET / CT

Sponsor: Peking University Cancer Hospital & Institute

PET/CT Imaging of GRPR Expression in Various Tumors

Trial ID: NCT07828678   Registry: ClinicalTrials.gov

Intervention: GRPR PET/CT

Condition: Malignancies Multiple

Sponsor: Jewish General Hospital

PRISE (Personalized Response and Immunologic Surveillance of Endogenous C-Peptide Preservation in New, Recent, and Established Onset Type 1 Diabetes Treated With Human Anti-Thymocyte Globulin [h-ATG]) Study

Trial ID: NCT07670650   Registry: ClinicalTrials.gov

Intervention: SAB-142, Placebo

Condition: Type 1 Diabetes (T1D)

Sponsor: University of Florida

Locations: 43 active-listed locations

Partially Hydrolyzed Whey Protein Formula for Infants With Mild Allergy

Trial ID: NCT07449507   Registry: ClinicalTrials.gov

Intervention: Partially Hydrolyzed Whey Protein Formula, Intact Cow's Milk Protein Formula

Condition: Mild Allergic Symptoms in Infants, Infant Feeding Intolerance

Sponsor: Ruijin Hospital

Peptide Nanovaccine (ONVAX-01) Plus Anti-PD-1 Antibody and Chemotherapy in Advanced Pancreatic Cancer

Trial ID: NCT07637786   Registry: ClinicalTrials.gov

Intervention: ONVAX-01 plus Anti-PD-1 and Chemotherapy

Condition: Advanced Pancreatic Adenocarcinoma

Sponsor: Sichuan University

Locations: 1 active-listed location

Personalized Vaccine for TNBC Immunotherapy

Trial ID: NCT06195618   Registry: ClinicalTrials.gov

Intervention: Peptide (neoantigen) pulsed autologous Dendritic cell

Condition: Breast Cancer Female

Sponsor: Universidad Nacional de Colombia

Locations: 1 active-listed location

Phase IIa/b Trial of PvCS/Montanide ISA-51 Malaria Vaccine in Adults in Chocó, Colombia

Trial ID: NCT07373301   Registry: ClinicalTrials.gov

Intervention: PvCS/Montanide ISA-51 VG Vaccine, Placebo - Montanide ISA-51 VG Adjuvant Alone

Condition: Plasmodium Vivax Malaria, Plasmodium Vivax Infection, Malaria Prevention

Sponsor: Malaria Vaccine and Drug Development Center

Locations: 1 active-listed location

Pilot Assessment of the Safety of a Combination of Curcumin, Omega-3, and Vitamin D Supplements in ACPA+ Individuals

Trial ID: NCT06478290   Registry: ClinicalTrials.gov

Intervention: curcumin, omega-3, and vitamin D (COD)

Condition: Healthy Participants

Sponsor: University of Manitoba

Locations: 2 active-listed locations

Postprandial Regulation of Bone Perfusion in Healthy Individuals

Trial ID: NCT07679516   Registry: ClinicalTrials.gov

Intervention: isotonic saline infusion, Infusion of GIP(1-42), Infusion of GLP-2(1-33), Infusion of pramlintide

Condition: Healthy Adult Participants, Bone Physiology, Bone Blood Flow Regulation, Peptide Hormones

Sponsor: University of Copenhagen

Locations: 1 active-listed location

Preoperative Oral Carbohydrate Loading in Patients With Type 2 Diabetes Undergoing Gastrointestinal Surgery

Trial ID: NCT07830537   Registry: ClinicalTrials.gov

Intervention: Standard ERAS Fasting and Clear-Fluid Management, Oral Carbohydrate Loading, Intravenous Glucose

Condition: Type 2 Diabetes Mellitus (DM), Gastrointestinal Surgery

Sponsor: The Affiliated Hospital of Qingdao University

Preoperative Semaglutide Prior to Radical Prostatectomy

Trial ID: NCT07727473   Registry: ClinicalTrials.gov

Intervention: Semaglutide 2.4 mg

Condition: Prostate Cancer

Sponsor: Banner Health

Locations: 1 active-listed location

Prevention of Chronic Kidney Disease(CDK) Progression in Type 1 Diabetes With Long Term Use of Sodium-Glucose-coTransporter Inhibitors Avoiding Kidney hypOxia

Trial ID: NCT06147232   Registry: ClinicalTrials.gov

Intervention: Sotagliflozin, Placebo

Condition: Nephropathy, Diabetic Nephropathies, Diabetes Mellitus, Type 1, Albuminuria, Diabetic Complications Renal, Diabetic Complications Cardiovascular, Hypoxia

Sponsor: Steno Diabetes Center Copenhagen

Locations: 2 active-listed locations

ProGo Menopause Wellbeing Study

Trial ID: NCT07611305   Registry: ClinicalTrials.gov

Intervention: Salmon protein hydrolysate (SPH) powder formulated into a tablet format, Microcrystalline Cellulose

Condition: Menopause Related Conditions

Sponsor: Hofseth Biocare ASA

Locations: 1 active-listed location

Prospective i-FactorTM Analysis Fusion Rate and Quality of Life

Trial ID: NCT04610021   Registry: ClinicalTrials.gov

Intervention: i-FactorTM Bone graft

Condition: Spinal Deformity, Bone Graft, Fusion Rate, Quality of Life

Sponsor: Complejo Asistencial Universitario de León Urgencias

Locations: 1 active-listed location

RDN for Heart Failure

Trial ID: NCT07558902   Registry: ClinicalTrials.gov

Intervention: Renal denervation

Condition: Heart Failure

Sponsor: Shanghai Golden Leaf MedTec Co. Ltd

Locations: 1 active-listed location

RGD With Minimally Invasive Non-Surgical Technique in Treatment of Periodontal Intrabony Defect

Trial ID: NCT06936605   Registry: ClinicalTrials.gov

Intervention: RGD Peptide

Condition: Intrabony Defect, Periodontal Diseases, Alveolar Bone Loss

Sponsor: Minia University

Recombinant Human Brain Natriuretic Peptide for the Recovery Stage of Septic Shock

Trial ID: NCT06745206   Registry: ClinicalTrials.gov

Intervention: Lyophilized Recombinant Human Brain Natriuretic Peptide

Condition: Sepsis-induced Cardiomyopathy, the Recovery Phase of Septic Shock

Sponsor: Sichuan Provincial People's Hospital

Relaxin Therapy for Atrial Fibrillation

Trial ID: NCT07359872   Registry: ClinicalTrials.gov

Intervention: Relaxin, Placebo

Condition: Atrial Fibrillation (AF), Arrhythmia, Oxidative Stress, Stroke, Major Cardiovascular Event, Heart Failure, Catheter Ablation, Ablation of Atrial Fibrillation

Sponsor: Deeptankar DeMazumder

Rimegepant-Sensitized Neoadjuvant Chemoimmunotherapy for Oral or Oropharyngeal Squamous Cell Carcinoma

Trial ID: NCT07812467   Registry: ClinicalTrials.gov

Intervention: Rimegepant, Tislelizumab, Nab-paclitaxel, Cisplatin

Condition: Oral Squamous Cell Carcinoma (OSCC), Oropharyngeal Squamous Cell Carcinoma (OPSCC)

Sponsor: Shanghai Zhongshan Hospital

Locations: 1 active-listed location

Risk Assessment of Pancreatic Islet Autoimmunity in Patients With AITD

Trial ID: NCT07494474   Registry: ClinicalTrials.gov

Intervention: Islet autoantibodies tested

Condition: Autoimmune Thyroid Disease

Sponsor: Nanjing Medical University

SENSILINS: Impact of Cephalic Phase Insulin Release Induced by an Environmental Food Odor Stimulus on Glucose Homeostasis According to Insulin Sensitivity Level

Trial ID: NCT07638111   Registry: ClinicalTrials.gov

Intervention: Pleasant Food Odor Stimulation, Control Environmental Condition

Condition: Obesity & Overweight, Insulin Resistance Syndrome

Sponsor: Hospices Civils de Lyon

Locations: 1 active-listed location

SHIELD-T1D: Shingrix and GLP-1 Agonist for Beta-Cell Preservation in Recent-Onset Type 1 Diabetes.

Trial ID: NCT07614412   Registry: ClinicalTrials.gov

Intervention: Recombinant Zoster Vaccine (Shingrix; RZV), Semaglutide (Ozempic®), Placebo (saline injection)

Condition: Type 1 Diabetes Mellitus

Sponsor: Ministry of Health, Saudi Arabia

Locations: 1 active-listed location

Safety and Tolerability of NCP-IL-22BP mRNA in Advanced Solid Tumors

Trial ID: NCT07562815   Registry: ClinicalTrials.gov

Intervention: 25 μg NCP-IL-22BP mRNA, 50 μg NCP-IL-22BP mRNA, 100 μg NCP-IL-22BP mRNA

Condition: Cancer

Sponsor: West China Hospital

Locations: 1 active-listed location

Safety and Tolerability of a mRNA Vaccine Encoding Tumor-Specific Circular RNA Antigens in Combination With Anti-PD-1 Monoclonal Antibody in Patients With Advanced Solid Tumors

Trial ID: NCT07245901   Registry: ClinicalTrials.gov

Intervention: circFAM53B mRNA vaccine, toripalimab

Condition: Solid Tumor

Sponsor: Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

Safety, Tolerability, and Preliminary Antitumor Activity of Non-Cationic Peptide-CD47 siRNA in Advanced Solid Tumors

Trial ID: NCT07583914   Registry: ClinicalTrials.gov

Intervention: NCP-CD47 siRNA intratumorally injection

Condition: Solid Tumor Cancer, Metastases, Head and Neck Cancer

Sponsor: West China Hospital

Sequential Immune Modulation and Antigen-Specific Tolerance Induction for Disease Modification in Recent-Onset Type 1 Diabetes

Trial ID: NCT07610213   Registry: ClinicalTrials.gov

Intervention: Teplizumab, Intralymphatic Insulin Immunotherapy (ILIT)

Condition: Type 1 Diabetes Mellitus (T1DM), Type 1 Diabetes Mellitus, Autoimmune Diabetes

Sponsor: Abdullah Kars

Locations: 1 active-listed location

Serum Anti-PCOLCE as Novel Diagnostic Biomarker in Rheumatoid Arthritis With Emphasis on Seronegative Patients.

Trial ID: NCT07129837   Registry: ClinicalTrials.gov

Intervention: Clinical evaluation, disease activity and disability scoring, and laboratory testing including RF, anti-CCP, and serum anti-PCOLCE antibody measurement by ELISA.

Condition: Rheumatoid Arthritis

Sponsor: Assiut University

Somatostatin Analogues vs. Observation After Peptide Receptor Radionuclide Therapy (PRRT) in Nonfunctional Neuroendocrine Neoplasms

Trial ID: NCT07842172   Registry: ClinicalTrials.gov

Intervention: Somatostatin Analogue(s)

Condition: Neuroendocrine Neoplasm, Gastroenteropancreatic Neuroendocrine Neoplasm

Sponsor: Washington University School of Medicine

Locations: 2 active-listed locations

Study on the Efficacy and Mechanism of METTL3 Peptide Inhibitors in Enhancing Anti-tumor Immune Response by Reshaping the Tumor Microenvironment

Trial ID: NCT06762925   Registry: ClinicalTrials.gov

Intervention: No Interventions

Condition: Bladder Cancer, Prostate Cancer, Kidney Cancer

Sponsor: Xijing Hospital

Supplementation of Gut-brain Axis (GLP-1)-Activating Carbohydrates for Increasing Satiety in Adolescents With Obesity

Trial ID: NCT07823452   Registry: ClinicalTrials.gov

Intervention: gut-brain axis (GLP-1)-activating food carbohydrate, starch-based placebo control (commercial maltodextrin)

Condition: Obesity & Overweight

Sponsor: Indiana University

Locations: 1 active-listed location

Tear Biomarkers for Migraine

Trial ID: NCT07690696   Registry: ClinicalTrials.gov

Intervention: Patients with migraine

Condition: Migraine

Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Testing the SurVaxM Vaccine for Lung Cancer Prevention

Trial ID: NCT07169617   Registry: ClinicalTrials.gov

Intervention: Biospecimen Collection, Montanide ISA 51 VG, Questionnaire Administration, Sargramostim, SVN53-67/M57-KLH Peptide Vaccine

Condition: Lung Carcinoma

Sponsor: National Cancer Institute (NCI)

Locations: 4 active-listed locations

The AgRP and GH/IGF-1 Axis in Children

Trial ID: NCT05645211   Registry: ClinicalTrials.gov

Condition: Growth Hormone Deficiency

Sponsor: Columbia University

The CGM-OGTT Glycemic Homeostasis Study

Trial ID: NCT07288372   Registry: ClinicalTrials.gov

Condition: Type 2 Diabetes, Glucose Metabolism Disorders

Sponsor: Shanghai 6th People's Hospital

The Clinical Trial of Tamibarotene for Patients With HFpEF (RELIEF Trial)

Trial ID: NCT07855692   Registry: ClinicalTrials.gov

Intervention: Tamibarotene, Placebo

Condition: HFpEF - Heart Failure With Preserved Ejection Fraction

Sponsor: Nagoya University

Locations: 4 active-listed locations

The Role of Transcutaneous Vagus Nerve Stimulation in Treatment of Acute Brain Injury

Trial ID: NCT07384845   Registry: ClinicalTrials.gov

Intervention: transcutaneous vagus nerve stimulation (tVNS), Sham (No Treatment)

Condition: Acute Brain Injury, Transcutaneous Vagus Nerve Stimulation, Neuromodulation, Immunomodulation

Sponsor: Clinical Hospital Centre Zagreb

Locations: 1 active-listed location

The T1DWATCH Study: a Screening for Type 1 Diabetes Autoantibodies in Children for Early Detection and Intervention.

Trial ID: NCT07492550   Registry: ClinicalTrials.gov

Condition: Diabete Type 1

Sponsor: Fabiana Sherine Ganem dos Santos

Tirzepatide in Thrombectomy-Treated Acute Ischemic Stroke: A Randomized Trial

Trial ID: NCT07734792   Registry: ClinicalTrials.gov

Intervention: Tirzepatide, Standard Medical Care (SMC)

Condition: Acute Ischemic Stroke (AIS)

Sponsor: yifang zhu

Locations: 1 active-listed location

Tirzepatide on Atrial Fibrillation Recurrence After Catheter Ablation in Patients With Obesity and HFpEF

Trial ID: NCT07630454   Registry: ClinicalTrials.gov

Intervention: Tirzepatide, Structured Lifestyle Intervention

Condition: Atrial Fibrillation, Heart Failure With Preserved Ejection Fraction (HFpEF), Tirzepatide

Sponsor: Yunlong Wang

Locations: 1 active-listed location

Trial of Lu-177 DOTATATE (Lutathera®) in Unlicensed Indications

Trial ID: NCT06121271   Registry: ClinicalTrials.gov

Intervention: Lu-177 DOTATATE (Lutathera®)

Condition: Bronchial and Thymic Neuroendocrine Tumour, Paraganglioma/ Phaeochromocytoma, Medullary Thyroid Carcinoma, Those Requiring Repeat Peptide Receptor Radionuclide Therapy

Sponsor: University College, London

UNDERSTANDING THE T-CELL AND B-CELL RECEPTOR REPERTOIRE IN CHILDREN AND YOUNG ADULTS WITH ANTI-DRUG ANTIBODIES AGAINST PEG ASPARAGINASE

Trial ID: NCT07499336   Registry: ClinicalTrials.gov

Intervention: Hypersensitivity reaction to asparaginase

Condition: Acute Lymphoblastic Leukaemia - Category

Sponsor: Aarhus University Hospital

Validation of New Biomarkers for Predicting No-Reflow in STEMI Patients Undergoing Primary PCI

Trial ID: NCT07132489   Registry: ClinicalTrials.gov

Intervention: HbA1c/C-peptide ratio Albumin-bilirubin (ALBI) score. Neutrophil/HDL ratio

Condition: Myocardial Infarction, No Reflow Phenomenon

Sponsor: Assiut University

Weight Changes After Incretin-mimetics

Trial ID: NCT06795360   Registry: ClinicalTrials.gov

Intervention: discontinuation of weight loss medication

Condition: Obesity and Obesity-related Medical Conditions

Sponsor: Medical College of Wisconsin

mHealth Intervention to Support Self-care During the Hospital to Home Transition in Individuals With Heart Failure

Trial ID: NCT07478081   Registry: ClinicalTrials.gov

Intervention: mHealth Educational Self-Management Application, Usual transitional care

Condition: Heart Failure, Self-care, Transitional Care

Sponsor: Universidad de la Sabana

Locations: 1 active-listed location

rhBNP for Prevention of Cardiac Surgery-Associated Acute Kidney Injury (CSA-AKI)

Trial ID: NCT07617675   Registry: ClinicalTrials.gov

Intervention: Recombinant Human Brain Natriuretic Peptide (rhBNP), Normal Saline (Placebo)

Condition: AKI - Acute Kidney Injury, Cardiac Surgical Procedures, Cardiopulmonary Bypass

Sponsor: China National Center for Cardiovascular Diseases

Locations: 1 active-listed location

"Receptor Radionuclide Therapy With 177Lu-DOTATOC

Trial ID: NCT06045260   Registry: ClinicalTrials.gov

Intervention: 177Lu-DOTATOC

Condition: Neuroendocrine Tumors, Paraganglioma, Pheochromocytoma

Sponsor: Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS

Locations: 2 active-listed locations

64Cu-GRIP B in Patients With Advanced Malignancies

Trial ID: NCT05888532   Registry: ClinicalTrials.gov

Intervention: Copper-64 labeled Granzyme B (64Cu-GRIP B), Positron Emission Tomography (PET)

Condition: Prostate Cancer, Renal Cancer, Urethral Cancer, Advanced Solid Tumor, Metastatic Castration-resistant Prostate Cancer, Solid Tumor, Adult

Sponsor: Rahul Aggarwal

Locations: 1 active-listed location

68Ga-DOTATOC PET for the Evaluation of Gastroenteropancreatic Neuroendocrine Tumours

Trial ID: NCT06155318   Registry: ClinicalTrials.gov

Intervention: 68Ga-DOTATOC PET as a part of their clinical diagnostic work-up will be included

Condition: Gastroenteropancreatic Neuroendocrine Tumor

Sponsor: IRCCS San Raffaele

Locations: 1 active-listed location

A DNAJB1-PRKACA Fusion Kinase Peptide Vaccine Combined With Glutamine Antagonist DRP-104, Nivolumab, and Ipilimumab in Patients With Advanced Stage Fibrolamellar Carcinoma (FLC)

Trial ID: NCT07430202   Registry: ClinicalTrials.gov

Intervention: DNAJB1-PRKACA Peptide Vaccine, DRP-104, Nivolumab, Ipilimumab

Condition: Liver Cancer (Fibrolamellar Hepatocellular Cancer (FLC))

Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Locations: 1 active-listed location

A Molecular Probe Targeting BCMA for the Clinical Diagnosis of Multiple Myeloma

Trial ID: NCT06717113   Registry: ClinicalTrials.gov

Intervention: 18F-FDG, 68Ga-BC1

Condition: Multiple Myeloma and Malignant Plasma Cell Neoplasms

Sponsor: Peking University First Hospital

Locations: 2 active-listed locations

A Multicenter Pharmacoepidemiological Cohort on Real Life Use of Semaglutide in Adolescents or Adults With Monogenic Obesity

Trial ID: NCT06380426   Registry: ClinicalTrials.gov

Condition: Monogenic Obesity

Sponsor: Assistance Publique - Hôpitaux de Paris

Locations: 2 active-listed locations

A Non-interventional Study of Melphalan Flufenamide (Melflufen) (Pepaxti®) and Dexamethasone in Patients With Relapsed and/or Refractory Multiple Myeloma (R/RMM)

Trial ID: NCT07559799   Registry: ClinicalTrials.gov

Condition: Multiple Myeloma

Sponsor: iOMEDICO AG

Locations: 1 active-listed location

A Pan-European Post-Authorisation Safety Study: Risk of Pancreatic Cancer Among Type 2 Diabetes Patients Who Initiated Exenatide as Compared With Those Who Initiated Other Non-Glucagon-Like Peptide 1 Receptor Agonists Based Glucose Lowering Drugs

Trial ID: NCT05663515   Registry: ClinicalTrials.gov

Intervention: Exenatide, Non-GLP-1 RA based glucose lowering drugs

Condition: Pancreatic Cancer

Sponsor: AstraZeneca

Locations: 8 active-listed locations

A Phase 1 Study of 99mTc-p5+14 in Healthy Volunteers and Patients With AL or ATTR Systemic Amyloidosis

Trial ID: NCT05951816   Registry: ClinicalTrials.gov

Intervention: 99mTc-p5+14 is an amyloid reactive peptide labeled with technetium-99m., 99mTc-Pyrophosphate

Condition: Systemic Amyloidosis

Sponsor: University of Tennessee Graduate School of Medicine

Locations: 1 active-listed location

A Phase 1, First-in-Human (FIH), Open-Label, Dose-Escalation and Dose Expansion Study of the Peptide Drug Conjugate (PDC), TS-104, as a Monotherapy in Subjects With Select Advanced Solid Tumors

Trial ID: NCT07814248   Registry: ClinicalTrials.gov

Intervention: TS-104

Condition: NSCLC (Non-small Cell Lung Cancer), HNSCC, Endometrial, Ovarian Cancer, Esophageal Cancer, Head & Neck Cancer, Gastric Cancer (GC), Endometrial Cancer

Sponsor: TwoStep Therapeutics, Inc.

Locations: 3 active-listed locations

A Phase I Study to Assess the Safety and Efficacy of [225Ac]Ac-DOTATATE in Patients With SSTR+ GEP-Nens

Trial ID: NCT06732505   Registry: ClinicalTrials.gov

Intervention: [225Ac]Ac-DOTATATE

Condition: Neuroendocrine Neoplasm

Sponsor: Peking University Cancer Hospital & Institute

Locations: 1 active-listed location

A Phase I/II Trial to Preserve Residual Insulin Secretion in Children With Recent Onset Type 1 Diabetes by Giving Verapamil

Trial ID: NCT07199946   Registry: ClinicalTrials.gov

Intervention: Verapamil (Part A), Placebo

Condition: Type 1 Diabetes

Sponsor: Johnny Ludvigsson

Locations: 2 active-listed locations

A Study of GNTI-122 in Adults Recently Diagnosed With T1D

Trial ID: NCT06919354   Registry: ClinicalTrials.gov

Intervention: GNTI-122

Condition: Type 1 Diabetes (T1D), Type 1 Diabetes Mellitus

Sponsor: GentiBio, Inc

Locations: 10 active-listed locations

A Study of Orforglipron (LY3502970) in Participants With Type 2 Diabetes Who Observe Ramadan Fasting

Trial ID: NCT07613307   Registry: ClinicalTrials.gov

Intervention: Orforglipron

Condition: Diabetes Mellitus, Type 2, Diabetes Melletus, Glucose Metabolism Disorders, Metabolic Disorders, Nutritional and Metabolic Diseases, Endocrine System Diseases, Feeding Behavior, Behavior, Fasting, Glucagon-Like Peptide-1 Receptor, Glucagon-Like Peptide Receptors, Receptors, G-Protein-Coupled, Receptors, Cell Surface, Membrane Proteins, Proteins, Receptors, Peptide

Sponsor: Eli Lilly and Company

Locations: 40 active-listed locations

A Study of Pegmolesatide of in Dialysis Chronic Kidney Disease (CKD) Patients With Anemia Treated With Hypoxia-inducible Factor Prolyl Hydroxylase Inhibitor (HIF-PHI)

Trial ID: NCT07136792   Registry: ClinicalTrials.gov

Intervention: Pegmolesatide 2mg SC, Pegmolesatide 4mg SC, Pegmolesatide 6mg SC

Condition: Renal Anemia of Chronic Kidney Disease

Sponsor: Guangdong Provincial People's Hospital

Locations: 24 active-listed locations

A Study of Theranostic Pair PD-32766D/T in Participants With Carbonic Anhydrase IX Positive Clear Cell Renal Cell Carcinoma

Trial ID: NCT07688187   Registry: ClinicalTrials.gov

Intervention: PD-32766D (a Copper-64 [64Cu] labeled peptide), PD-32766T (an Actinium-225 [225Ac] labeled peptide)

Condition: Clear Cell Renal Cell Carcinoma

Sponsor: PeptiDream Inc.

Locations: 1 active-listed location

A Study of [177Lu]Lu-A9-0631 and [225Ac]Ac-A9-0642 With [68Ga]Ga-A9-6217 or [177Lu]Lu-A9-0631 Imaging in GRPR+ Solid Tumors

Trial ID: NCT07661641   Registry: ClinicalTrials.gov

Intervention: [68Ga]Ga-A9-6217, Low dose [177Lu]Lu-A9-0631, [177Lu]Lu-A9-0631, [225Ac]Ac-A9-0642

Condition: Breast Cancer, Prostate Cancer, Colorectal Cancer, GRPR-positive Solid Tumors

Sponsor: Alpha-9 Oncology USA Inc.

Locations: 2 active-listed locations

A Study to Estimate Early Clinical Efficacy Signals of GLP-1 Agonist Administration in Conjunction With Levonorgestrel Intrauterine Device in Obese Patients With Endometrioid Intraepithelial Neoplasia

Trial ID: NCT07107334   Registry: ClinicalTrials.gov

Intervention: Glucagon-like peptide 1 receptor agonist

Condition: Endometrioid Endometrial Adenocarcinoma

Sponsor: University of Florida

Locations: 1 active-listed location

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of RLS-0071 in Newborns With Moderate or Severe Hypoxic-Ischemic Encephalopathy Undergoing Therapeutic Hypothermia

Trial ID: NCT05778188   Registry: ClinicalTrials.gov

Intervention: RLS-0071, Placebo

Condition: Hypoxic-Ischemic Encephalopathy

Sponsor: ReAlta Life Sciences, Inc.

Locations: 15 active-listed locations

A Study to Learn About the Study Medicine Called Rimegepant in Adults When Used for the Prevention of Chronic Migraine

Trial ID: NCT07729462   Registry: ClinicalTrials.gov

Intervention: Rimegepant, Placebo

Condition: Preventive Treatment of Migraine

Sponsor: Pfizer

Locations: 19 active-listed locations

A Trial Within Cohort Feasibility Study Design Comparing Standard of Care Versus Weight Loss (Achieved Through Tirzepatide) for Obesity-related Hypertension in Young Adults

Trial ID: NCT07364175   Registry: ClinicalTrials.gov

Intervention: Tirzepatide, Anti-Hypertensive medications

Condition: Hypertension, Obesity & Overweight

Sponsor: Cambridge University Hospitals NHS Foundation Trust

Locations: 1 active-listed location

A Vaccine (H2NVAC) Before Surgery for the Treatment of HER2-Expressing Ductal Carcinoma In Situ

Trial ID: NCT04144023   Registry: ClinicalTrials.gov

Intervention: Granulocyte-Macrophage Colony-Stimulating Factor, Multi-epitope HER2 Peptide Vaccine H2NVAC, Therapeutic Conventional Surgery, Echocardiography Test, Biospecimen Collection, Biopsy Procedure

Condition: Breast Ductal Carcinoma In Situ

Sponsor: Mayo Clinic

Locations: 2 active-listed locations

A Vaccine Trial for Low Grade Gliomas

Trial ID: NCT02358187   Registry: ClinicalTrials.gov

Intervention: Experimental: HLA-A2 Restricted Glioma Antigen-Peptides with Poly-ICLC

Condition: Low Grade Glioma

Sponsor: James Felker

Locations: 1 active-listed location

ACE Reno, Pico Cell Matrix and Its Effect on eGFR in Chronic Kidney Diseases

Trial ID: NCT07187713   Registry: ClinicalTrials.gov

Intervention: ACE Reno

Condition: Hypertensive Nephropathy, Auto Immune Disorders, Chronic Kidney Disease, Chronc Kidney Disease Stage 5, Chronic Kidney Disease (Stage 3-4), Chronic Kidney Disease (Stages 4 and 5), Microalbuminuria, Diabetic Nephropathies

Sponsor: Ace Cells Lab Limited

Locations: 1 active-listed location

AMBulatory UltraSound for Heart Failure Management

Trial ID: NCT04741711   Registry: ClinicalTrials.gov

Intervention: An ultrasound (lung and inferior vena cava) will be performed and the heart failure treatments will be guided by the results of the lung ultrasound and the evaluation of the inferior vena cava., Usual care without ultrasound guidance

Condition: Heart Failure

Sponsor: Central Hospital, Nancy, France

Locations: 5 active-listed locations

ATRA and Carfilzomib in Plasma Cell Myeloma Patients

Trial ID: NCT06536413   Registry: ClinicalTrials.gov

Intervention: All-Trans Retinoic Acid (ATRA) Dose 0, All-Trans Retinoic Acid (ATRA) Dose -1, All-Trans Retinoic Acid (ATRA) Dose 1

Condition: Multiple Myeloma

Sponsor: The Methodist Hospital Research Institute

Locations: 1 active-listed location

Absorbed Tumor Dose in Peptide Receptor Radionuclide Therapy with Long-acting Somatostatin Analogues - ATSA Trial

Trial ID: NCT06855095   Registry: ClinicalTrials.gov

Intervention: Somatostatin analog

Condition: Neuroendocrine Tumors, Neuroendocrine Tumor Grade 1, Neuroendocrine Tumor Grade 2, Neuroendocrine Neoplasm

Sponsor: The Netherlands Cancer Institute

Locations: 1 active-listed location

Acute Heart Failure - COngestion Discharge Evaluation

Trial ID: NCT04332692   Registry: ClinicalTrials.gov

Intervention: Clinical examination centered on congestion, Cardiac, pulmonary, peritoneal, jugular, renal Doppler ultrasounds and liver elastography, Blood sample retrieved for biological assessment and biobanking, Telephone follow-up, Kansas City Cardiomyopathy Questionnaire (KCCQ)

Condition: Acute Heart Failure

Sponsor: Central Hospital, Nancy, France

Locations: 1 active-listed location

Acute Metabolic Effects of Tirzepatide in Type 1 Diabetes

Trial ID: NCT06820281   Registry: ClinicalTrials.gov

Intervention: Tirzepatide 2.5mg weekly, Placebo injection (normal saline)

Condition: Type 1 Diabetes Mellitus

Sponsor: Victor Chang Cardiac Research Institute

Locations: 1 active-listed location

Acute Subcutaneous SemaglutidE in Acute Ischemic sTroke

Trial ID: NCT05630586   Registry: ClinicalTrials.gov

Intervention: Semaglutide, Standard care

Condition: Acute Ischemic Stroke

Sponsor: Aarhus University Hospital

Locations: 1 active-listed location

Alleviating Carbohydrate Counting for Patients with Type-1 Diabetes Using a Closed Loop System with Weekly Subcutaneous Semaglutide

Trial ID: NCT06387199   Registry: ClinicalTrials.gov

Intervention: Semaglutide with 4 meal strategies, Placebo with 4 meal strategies

Condition: Type 1 Diabetes, Diabetes Mellitus

Sponsor: McGill University Health Centre/Research Institute of the McGill University Health Centre

Locations: 1 active-listed location

An Artificial Intelligence-powered Approach to Precision Immunotherapy of Human Arthritis

Trial ID: NCT07013110   Registry: ClinicalTrials.gov

Intervention: dnaJP1, Placebo

Condition: Rheumatoid Arthritis (RA), Rheumatology

Sponsor: Prof Salvatore Albani

Locations: 1 active-listed location

Asian Diabetes Outcomes Prevention Trial

Trial ID: NCT04286399   Registry: ClinicalTrials.gov

Intervention: Renin-angiotensin-aldosterone system inhibitors, Beta blocker, SGLT2 Inhibitor - Sodium Glucose Cotransporter Subtype 2 Inhibitor Product

Condition: Diabetes Mellitus, Cardiovascular Diseases

Sponsor: National Heart Centre Singapore

Locations: 1 active-listed location

Assessment of Serum Catestatin Level in Acne Vulgaris Patients

Trial ID: NCT07054398   Registry: ClinicalTrials.gov

Intervention: Isotretinoin

Condition: Acne Vulgaris

Sponsor: Aswan University

Locations: 1 active-listed location

Association of Plasma N-terminal Pro-Brain Natriuretic Peptide Levels With the Burden of Coronary Artery Disease

Trial ID: NCT07013344   Registry: ClinicalTrials.gov

Intervention: BNP

Condition: Chronic Coronary Syndrome, Chronic Coronary Total Occlusion, Coronary Arterial Disease (CAD), Stable Chronic Angina, NT-pro-BNP

Sponsor: IRCCS Ospedale San Raffaele

Locations: 2 active-listed locations

Atrial Appendage Micrograft Transplants to Assist Heart Repair After Cardiac Surgery

Trial ID: NCT05632432   Registry: ClinicalTrials.gov

Intervention: Epicardial AAMs-patch transplantation, RNA-stabilized whole blood sampling, Plasma sampling, Transthoracic echocardiography, Late-gadolinium enhancement cardiac magnetic resonance imaging (LGE-CMRI), Symptom-scaling, 6-minute walking test (6MWT), Blood sampling (NT-proBNP), Transesophageal echocardiography, Epicardial collagen-based patch transplantation

Condition: Ischemic Heart Disease, Ischemic Cardiomyopathy, Heart Failure, Systolic, Heart Failure NYHA Class III, Heart Failure NYHA Class II, Heart Failure NYHA Class IV, Coronary Artery Disease

Sponsor: Hospital District of Helsinki and Uusimaa

Locations: 1 active-listed location

Autologous Dendritic Cell Vaccine For Recurrent Respiratory Papillomatosis (RRP) Patients

Trial ID: NCT07317154   Registry: ClinicalTrials.gov

Intervention: Autologous HPV6 E6-and E7-derived peptide-loaded dendritic cell

Condition: Recurrent Respiratory Papillomatosis

Sponsor: Mayo Clinic

Locations: 1 active-listed location

Autologous Neoantigen-Specific T-Cell Therapy for Advanced Hepatocellular Carcinoma

Trial ID: NCT07123545   Registry: ClinicalTrials.gov

Intervention: iNeo-Vac-P01 Personalized Neoantigen Peptide Vaccine, iNeo-Vac-T01 Personalized T Cell Injection

Condition: Advanced Hepatocellular Carcinoma (HCC)

Sponsor: Zhejiang University

Locations: 1 active-listed location

BPC 157 for Acute Hamstring Muscle Strain Repair

Trial ID: NCT07437547   Registry: ClinicalTrials.gov

Intervention: Pentadecapeptide BPC 157, Placebo

Condition: Hamstring Muscle Strain, Skeletal Muscle Injury

Sponsor: Hudson Biotech

Locations: 1 active-listed location

BZLF1 Peptide Vaccine (OSU-2131) With QS-21 for the Prevention of Epstein-Barr Virus Related Cancer in Patients Awaiting Solid Organ Transplants

Trial ID: NCT06741072   Registry: ClinicalTrials.gov

Intervention: Biospecimen Collection, Dulbecco''s Phosphate-Buffered Saline, Peptide Vaccine, QS21

Condition: Chronic Kidney Disease, Stage 4, Chronic Kidney Disease, Stage 5, EBV-Related Lymphoproliferative Disorder, EBV-Related Malignant Neoplasm, Post-Transplant Lymphoproliferative Disorder

Sponsor: Ohio State University Comprehensive Cancer Center

Locations: 1 active-listed location

Benefits of Retained Insulin for Good Health

Trial ID: NCT07828626   Registry: ClinicalTrials.gov

Intervention: Observational

Condition: Diabetes (Insulin-requiring, Type 1 or Type 2), Diabetes, Diabetes (DM), Type 1 Diabetes (T1D)

Sponsor: Royal Devon and Exeter NHS Foundation Trust

Locations: 4 active-listed locations

Bevonescein for Improved Intraoperative Nerve Visualization to Improve Voice Outcomes in Thyroidectomy Patients

Trial ID: NCT07631650   Registry: ClinicalTrials.gov

Intervention: Bevonescein (ALM 488) Infusion

Condition: Head and Neck Disorder, Head and Neck Cancer

Sponsor: Matthew Spector

Locations: 1 active-listed location

Biomarkers and Cardiac Imaging Diagnostic Assay for Monitoring Patients With Fabry Disease

Trial ID: NCT05698901   Registry: ClinicalTrials.gov

Intervention: Agalsidase beta

Condition: Fabry Disease

Sponsor: Mackay Memorial Hospital

Locations: 1 active-listed location

Biomarkers for Ventilator-associated Pneumonia

Trial ID: NCT05117125   Registry: ClinicalTrials.gov

Intervention: Heparin-binding protein, Interleukin-26, Microbiome, Bacterial transcriptome, Proteome

Condition: Pneumonia, Ventilator-Associated

Sponsor: Region Skane

Locations: 5 active-listed locations

Biomarkers of Endometrial Receptivity

Trial ID: NCT04619524   Registry: ClinicalTrials.gov

Intervention: Cervical mucus will be collected from patients undergoing IVF, Cervical mucus will be collected from patients undergoing transfer of cryopreserved embryos

Condition: IVF, Infertility Treatment, Fertility Disorders, Embryo Transfer

Sponsor: The Institute of Molecular and Translational Medicine, Czech Republic

Locations: 3 active-listed locations

Biomarkers of Sleep-wake Cycle in Prodromal Alzheimer's Disease: Role in Cognitive Decline?

Trial ID: NCT05629871   Registry: ClinicalTrials.gov

Intervention: Polysomnography, Neuropsychological assessment, Questionnaires on sleep and behavioural problems, Actimetry, Fractional diuresis, Internal temperature measurement, Biomarker assay

Condition: Neuropathology

Sponsor: University Hospital, Montpellier

Locations: 3 active-listed locations

Body Composition and Exercise to Prevent Muscle Loss With GLP1 Agonist Treatment

Trial ID: NCT07226947   Registry: ClinicalTrials.gov

Intervention: Smartwatch activity and body composition monitor, General guidance on recommended exercise

Condition: Obesity, Body Composition

Sponsor: Massachusetts General Hospital

Locations: 1 active-listed location

Bone Metabolism in 12-21 Year Olds Undergoing Glucagon Like Peptide (GLP)-1 Receptor Agonist Therapy

Trial ID: NCT06903923   Registry: ClinicalTrials.gov

Intervention: GLP-1 receptor agonist, Lifestyle intervention

Condition: Obesity in Children, Bone Strength, GLP - 1, Lifestyle Modification, Bone Density, Obesity

Sponsor: University of Virginia

Locations: 1 active-listed location

Bradykinin-degradating Enzymes Activities in Angiotensin-Converting Enzyme Inhibitors-associated Angioedema

Trial ID: NCT04763577   Registry: ClinicalTrials.gov

Intervention: Assay of Bradykinin-degradating enzymes.

Condition: Angio-Oedema Caused by Angiotensin-Converting-Enzyme Inhibitor

Sponsor: University Hospital, Grenoble

Locations: 4 active-listed locations

Brown Adipose Tissue Activity in Response to Semaglutide Administered to Obese Subjects.

Trial ID: NCT05419726   Registry: ClinicalTrials.gov

Intervention: Semaglutide Injectable Product (not provided by the study)

Condition: Obesity

Sponsor: University of California, Los Angeles

Locations: 1 active-listed location

CARBON: UAB Cardiovascular Research Biobank

Trial ID: NCT05067231   Registry: ClinicalTrials.gov

Condition: Natriuretic Peptides, Cardiovascular Diseases, Hypertension, Diabetes, Obesity

Sponsor: University of Alabama at Birmingham

Locations: 1 active-listed location

CGRP Inhibition, Autonomic Function, and Migraine

Trial ID: NCT04628429   Registry: ClinicalTrials.gov

Intervention: Erenumab, Galcanezumab, Fremanezumab

Condition: Episodic Migraine, Chronic Migraine

Sponsor: Medical University of Vienna

Locations: 1 active-listed location

COLONYVAQ™, a Quantum-Classical Guided Personalized Neoantigen Vaccine for MSS Stage III Colorectal Cancer

Trial ID: NCT07328087   Registry: ClinicalTrials.gov

Intervention: Experimental: COLONYVAQ-CRC + mFOLFOX6 or CAPOX + Nivolumab

Condition: Colorectal Cancer Metastatic, Colorectal Cancer Stage III, Colorectal Cancer Stage IV

Sponsor: Biogenea Pharmaceuticals Ltd.

Locations: 1 active-listed location

CP: Intestinal Permeability

Trial ID: NCT07586930   Registry: ClinicalTrials.gov

Intervention: AP GUT collagen peptides, Placebo

Condition: Intestinal Permability

Sponsor: Rousselot BVBA

Locations: 1 active-listed location

Cell Free DNA in Cardiac Sarcoidosis

Trial ID: NCT03858777   Registry: ClinicalTrials.gov

Intervention: cell free DNA

Condition: Sarcoidosis With Myocarditis, Sarcoidosis, Healthy, ST Elevation Myocardial Infarction

Sponsor: Nabeel Hamzeh

Locations: 2 active-listed locations

Cessation of Somatostatin Analogues After PRRT in Mid, Hind-Gut and Pancreatic Neuroendocrine Tumours

Trial ID: NCT06345079   Registry: ClinicalTrials.gov

Intervention: Cessation of somatostatin analogues, Continuation of somatostatin analogues

Condition: Neuroendocrine Tumors

Sponsor: Australasian Gastro-Intestinal Trials Group

Locations: 17 active-listed locations

Characterization of Autoreactive Regulatory and Conventional CD4 T Cells in Recent Onset Type 1 Diabetes and Control Individuals

Trial ID: NCT06427421   Registry: ClinicalTrials.gov

Intervention: Frequency of Treg and Teffs, Phenotype of Treg and Teffs, RNA seq analysis, HLA typing, beta-cell autoantibody dosage, Glycated haemoglobin (HbA1C) dosage, blood glucose dosage, C-peptide dosage

Condition: Type 1 Diabetes

Sponsor: Assistance Publique - Hôpitaux de Paris

Locations: 1 active-listed location

Characterization of Immune Genotypes and Antibody Profiles to Foster the discoVERY of diagnosticbioMARKERS of Liver Cancer Development

Trial ID: NCT06718530   Registry: ClinicalTrials.gov

Condition: Hepatitis C Virus Infection

Sponsor: Centro di Riferimento Oncologico - Aviano

Locations: 4 active-listed locations

Chronic Widespread Pain in HIV: Novel Mechanisms and Therapeutics

Trial ID: NCT04787848   Registry: ClinicalTrials.gov

Intervention: Relistor Injectable Product

Condition: Chronic Widespread Pain

Sponsor: Florida International University

Locations: 1 active-listed location

Clinical Application Study of [123I]Metaiodobenzylguanidine and Somatostatin Receptor-Targeted Imaging in the Diagnosis and Staging of Neuroblastoma

Trial ID: NCT07064746   Registry: ClinicalTrials.gov

Intervention: ¹²³I-MIBG SPECT/CT, SSTR PET

Condition: Neuroblastoma (NB)

Sponsor: Nanjing First Hospital, Nanjing Medical University

Locations: 1 active-listed location

Clinical Application of FL-091 Radionuclide Imaging in Diagnosis and Staging of Malignant Tumors

Trial ID: NCT06977945   Registry: ClinicalTrials.gov

Intervention: Specific positron imaging agents targeting NTRS-1(FL-091)

Condition: Malignant Tumors With Positive NTSR1 Expression

Sponsor: Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

Locations: 1 active-listed location

Clinical Application of Somatostatin Receptor and Norepinephrine Transporter Targeted Imaging for Diagnosis and Staging of Neuroblastoma and Pheochromocytoma/Paraganglioma

Trial ID: NCT07195500   Registry: ClinicalTrials.gov

Condition: Neuroblastoma, Pheochromocytoma, Paraganglioma

Sponsor: Nanjing First Hospital, Nanjing Medical University

Locations: 1 active-listed location

Clinical Application of Stem Cell Educator Therapy in Type 1 Diabetes

Trial ID: NCT04011020   Registry: ClinicalTrials.gov

Intervention: Stem Cell Educator therapy

Condition: Type 1 Diabetes

Sponsor: Throne Biotechnologies Inc.

Locations: 2 active-listed locations

Clinical Study for the Safety and Therapeutic Efficacy of the AI-QMMM Designed TamavaqTM Personalised Vaccine in Patients With Newly Diagnosed Glioma.

Trial ID: NCT07077616   Registry: ClinicalTrials.gov

Intervention: Biological: personalized vaccine Based on genetic and transcriptional sequencing information, personalized peptide vaccines would be designed and produced;

Condition: Glioma

Sponsor: Biogenea Pharmaceuticals Ltd.

Locations: 1 active-listed location

Clinical, Morphometric and Biochemical Effects on Adiposopathy Associated With the Use of GLP-1RA in CKD

Trial ID: NCT07309094   Registry: ClinicalTrials.gov

Intervention: GLP-1 receptor agonist, SGLT2 inhibitor, Tirzepatide, Other drugs

Condition: Chronic Kidney Disease stage3, Chronic Kidney Disease stage4, Chronic Kidney Disease Stage 1, Chronic Kidney Disease Stage 2, Obesity, Diabetes Mellitus, Type 2

Sponsor: Cardenal Herrera University

Locations: 1 active-listed location

Collagen Peptides and Cellular Aging

Trial ID: NCT07456449   Registry: ClinicalTrials.gov

Intervention: Collagen peptides, Maltodextrin (Placebo)

Condition: Longevity, Healthy Aging, Biological Ageing

Sponsor: University of Vienna

Locations: 1 active-listed location

Combination External Radiation and PRRT for Large GI Neuroendocrine Tumors.

Trial ID: NCT07150546   Registry: ClinicalTrials.gov

Intervention: Stereotactic Body Radiation Therapy, Lutetium Lu 177 Dotatate, Computed Tomography, Magnetic Resonance Imaging, Gallium Ga 68-DOTATATE, Positron Emission Tomography, Questionnaire Administration

Condition: Digestive System Neuroendocrine Tumor, Unresectable Digestive System Neuroendocrine Neoplasm, Unresectable Digestive System Neuroendocrine Tumor G1, Unresectable Digestive System Neuroendocrine Tumor G2

Sponsor: Emory University

Locations: 2 active-listed locations

Combination of CAR-DC Vaccine and ICIs in Malignant Tumors

Trial ID: NCT05631886   Registry: ClinicalTrials.gov

Intervention: TP53-EphA-2-CAR-DC, Abraxane, Cyclophosphamide, anti-PD-1 antibody, Anti-CTLA4 Monoclonal Antibody

Condition: Solid Tumor, Adult, Lymphoma, EphA2 Overexpression, TP53 R273H, TP53 R175H, TP53 R248Q, TP53 R249S

Sponsor: Chinese PLA General Hospital

Locations: 1 active-listed location

Combination of Everolimus and 177Lu-DOTATATE in the Treatment of Grades 2 and 3 Refractory Meningioma: a Phase IIb Clinical Trial

Trial ID: NCT06126588   Registry: ClinicalTrials.gov

Intervention: Everolimus

Condition: Meningioma

Sponsor: Central Hospital, Nancy, France

Locations: 2 active-listed locations

Combined Effects of Green Light and Transcranial Direct Current Stimulation in Migraine Patients.

Trial ID: NCT06943625   Registry: ClinicalTrials.gov

Intervention: tDCS, Green light, medicine

Condition: Migraine

Sponsor: Riphah International University

Locations: 2 active-listed locations

Comparing Retreatment of 177Lu-DOTATATE PRRT Versus the Usual Treatment in Patients With Metastatic Unresectable Gastroenteropancreatic Neuroendocrine Tumors, NET RETREAT Trial

Trial ID: NCT05773274   Registry: ClinicalTrials.gov

Intervention: Biospecimen Collection, Cabozantinib, Computed Tomography, Everolimus, Lutetium Lu 177 Dotatate, Magnetic Resonance Imaging, Quality-of-Life Assessment, Questionnaire Administration, Sunitinib

Condition: Metastatic Digestive System Neuroendocrine Tumor G1, Metastatic Digestive System Neuroendocrine Tumor G2, Unresectable Digestive System Neuroendocrine Tumor G1, Unresectable Digestive System Neuroendocrine Tumor G2

Sponsor: National Cancer Institute (NCI)

Locations: 41 active-listed locations

Comparison Between Two Instrumentation Techniques on Postoperative Pain and Level of Neuropeptides

Trial ID: NCT07357233   Registry: ClinicalTrials.gov

Intervention: Manual-less, Conventional technique

Condition: Post Operative Pain

Sponsor: Alexandria University

Locations: 1 active-listed location

Comparison of Clinical Efficacy of Submucosal Dexamethasone and Oral Trypsin-chymotrypsin for Reduction of Postoperative Sequelae After Lower Third Molar Surgery

Trial ID: NCT06713733   Registry: ClinicalTrials.gov

Intervention: Dexamethasone, Chymotrypsin

Condition: Clinical Efficacy of Submucosal Dexamethasone and Oral Trypsin Chymotrypsin for Reduction of Postoperative Sequelae After Lower Third Molar Surgery

Sponsor: B.P. Koirala Institute of Health Sciences

Locations: 1 active-listed location

Comparison of the Effects of General Anesthesia and Combined Spinal-Epidural Anesthesia on Ferroptosis, Humanin and MOTS-c Levels in Renal Transplantation

Trial ID: NCT07678073   Registry: ClinicalTrials.gov

Intervention: Sevoflurane General Anesthesia, Bupivacaine and Morphine for Combined Spinal-Epidural Anesthesia

Condition: Kidney Disease, End-Stage, Kidney Transplant, Kidney, Kidney Disease, Renal Transplant

Sponsor: University of Gaziantep

Locations: 1 active-listed location

Continuing Somatostatin Analogues Upon Progression in Neuroendocrine Tumour pAtients

Trial ID: NCT05701241   Registry: ClinicalTrials.gov

Intervention: Somatostatin analog

Condition: Gastroenteropancreatic Neuroendocrine Tumor

Sponsor: University Hospital, Antwerp

Locations: 19 active-listed locations

Current Status of Islet Alpha Cell Function in Patients with Type 2 Diabetes

Trial ID: NCT06825182   Registry: ClinicalTrials.gov

Intervention: Outpatient newly diagnosed type 2 diabetes subjects, Inpatient newly diagnosed type 2 diabetes subjects

Condition: Type 2 Diabetes Mellitus

Sponsor: Nanjing First Hospital, Nanjing Medical University

Locations: 1 active-listed location

DCEUS to Assess Treatment Response to PRRT in GEP-NET

Trial ID: NCT07319416   Registry: ClinicalTrials.gov

Intervention: Vuebox

Condition: NET, Radionucleide Therapy, Contrast Enhanced Ultrasound

Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Locations: 1 active-listed location

DNAJB1-PRKACA Fusion Kinase Peptide Vaccine Combined With Nivolumab and Ipilimumab for Patients With Fibrolamellar Hepatocellular Carcinoma

Trial ID: NCT04248569   Registry: ClinicalTrials.gov

Intervention: DNAJB1-PRKACA peptide vaccine, Nivolumab, Ipilimumab

Condition: Fibrolamellar Hepatocellular Carcinoma (FLC)

Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Locations: 1 active-listed location

Dietary Supplements and Middle Aged Women (Collagen & Omega)

Trial ID: NCT07740967   Registry: ClinicalTrials.gov

Intervention: Collagen peptides and omega-3, Placebo control

Condition: Cognition, Inflammation Biomarkers, Bone Metabolism Biomarkers, Fatigue Symptom, Sleep, Body Composition Changes, Joint Pain, Quality of Life, Gastrointestinal Comfort, Blood Pressure and Augmentation Index, Muscle Strength, Fatty Acid Blood Profile

Sponsor: Loughborough University

Locations: 1 active-listed location

Dosimetry Based PRRT Versus Standard Dose PRRT With Lu-177-DOTATOC in NEN Patients

Trial ID: NCT04917484   Registry: ClinicalTrials.gov

Intervention: Lu-177-DOTA-Octreotide

Condition: Neuroendocrine Neoplasm

Sponsor: Tine Gregersen, MD

Locations: 1 active-listed location

Echocardiography-Based Predictors of Outcomes in Hospitalized Patients With Decompensated Heart Failure (ECHO-DECOMP)

Trial ID: NCT07439159   Registry: ClinicalTrials.gov

Condition: Heart Failure

Sponsor: Istanbul University - Cerrahpasa

Locations: 1 active-listed location

Effect of C-peptide on Hypoglycemic Counterregulation

Trial ID: NCT06470295   Registry: ClinicalTrials.gov

Intervention: Saline, C-peptide

Condition: Hypoglycemia, Type 1 Diabetes

Sponsor: University of Cincinnati

Locations: 1 active-listed location

Effect of Gastric Electrical Stimulation on Serum Insulin Levels

Trial ID: NCT07635576   Registry: ClinicalTrials.gov

Intervention: Gastric Electrical Stimulator

Condition: Gastroparesis Nondiabetic

Sponsor: Indiana University

Locations: 1 active-listed location

Effect of Preoperative Oral Pregabalin Versus Intraoperative Fentanyl on Postoperative Analgesia

Trial ID: NCT05150795   Registry: ClinicalTrials.gov

Intervention: Pregabalin 150mg, Fentanyl 100 micrograms ampoule

Condition: Post Operative Pain, Acute

Sponsor: Ain Shams University

Locations: 1 active-listed location

Effect of Tirzepatide and Bimagrumab on Body Composition, Insulin Sensitivity, and Bone in Adults With Obesity

Trial ID: NCT05933499   Registry: ClinicalTrials.gov

Intervention: Bimagrumab, Tirzepatide, Calcium/Vitamin D, Lifestyle and nutrition counseling

Condition: Obesity

Sponsor: Massachusetts General Hospital

Locations: 1 active-listed location

Effect of Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) on Plasma Insulin Levels

Trial ID: NCT06597149   Registry: ClinicalTrials.gov

Intervention: Transcutaneous Auricular Vagus Nerve Stimulation, Sham Procedure (No Stimulation)

Condition: Healthy

Sponsor: Indiana University

Locations: 1 active-listed location

Effect of an Emollient Cream Containing a Milk Bioactive Peptide on Clinical Signs, Pruritus and Bacterial Colonization of Mild Atopic Dermatitis Skin Lesions in Pediatric Population

Trial ID: NCT07259343   Registry: ClinicalTrials.gov

Intervention: glycomacropeptide, emollient cream

Condition: Atopic Dermatitis (AD)

Sponsor: Universidad Autónoma de Aguascalientes

Locations: 1 active-listed location

Effect of the Consumption of Milk With Beta-casein A2A2, Milk With Beta-casein A1A2 and a Plant-based Drink on Metabolic Health in Adults: IMPA-CT Study

Trial ID: NCT07436260   Registry: ClinicalTrials.gov

Intervention: Consumption 500 ml of A1 milk., Consumption 500 ml of A2 milk, Consumption 500 ml of oat drink.

Condition: Healthy Participants

Sponsor: Dawid Madej

Locations: 1 active-listed location

Effectiveness and Tolerability of Zavegepant for Acute Migraine Treatment Among Those Using CGRP Targeting Preventive Medications

Trial ID: NCT06401642   Registry: ClinicalTrials.gov

Intervention: Zavegepant

Condition: Migraine

Sponsor: Mayo Clinic

Locations: 1 active-listed location

Effectiveness of a Dietary Supplement in Irritable Bowel Syndrome

Trial ID: NCT07039747   Registry: ClinicalTrials.gov

Intervention: treatment with DIELEN® Protect, treatment with placebo of DIELEN® Protect

Condition: Irritable Bowel Syndrome

Sponsor: University Hospital, Rouen

Locations: 1 active-listed location

Effects of Cerebrolysin on Language Ability in Non-fluent Aphasia Patients After Stroke: A Randomized, Placebo-controlled, Double-blinded, Single Center Study

Trial ID: NCT06897176   Registry: ClinicalTrials.gov

Intervention: Cerebrolyisin, Placebo

Condition: Stroke

Sponsor: Yonsei University

Locations: 1 active-listed location

Effects of Cetoleic Acid on Atherosclerosis (Ketolinsyre's Effekt på Aterosklerose)

Trial ID: NCT06172335   Registry: ClinicalTrials.gov

Intervention: Cetoleic acid, Control oil

Condition: Metabolic Syndrome

Sponsor: Oslo University Hospital

Locations: 1 active-listed location

Effects of Collagen Peptide Supplementation on Connective Tissue Remodeling, Functional Outcomes, and Wound Healing After Total Knee Arthroplasty (TKA)

Trial ID: NCT05823727   Registry: ClinicalTrials.gov

Intervention: SOLUGEL, Placebo

Condition: Knee Osteoarthritis

Sponsor: University of Arkansas

Locations: 1 active-listed location

Effects of GLP-1 Formula on GLP-1 and Glucose Regulation

Trial ID: NCT07082062   Registry: ClinicalTrials.gov

Intervention: GLP-1 formula Group

Condition: Overweight

Sponsor: Shih Chien Huang

Locations: 1 active-listed location

Effects of Glucagon-like Peptide-1 (GLP-1) Agonist in Neuro-reproductive Function in Obese Adolescent Females With Polycystic Ovary Syndrome (PCOS)

Trial ID: NCT07169136   Registry: ClinicalTrials.gov

Intervention: GLP-1 Receptor Agonists

Condition: Polycystic Ovarian Syndrome in Adolescent Females, Obesity (Disorder)

Sponsor: Nemours Children's Clinic

Locations: 1 active-listed location

Effects of Tirzepatide on Alcohol Intake in Patients Diagnosed With Schizophrenia and Alcohol Use Disorder

Trial ID: NCT06939088   Registry: ClinicalTrials.gov

Intervention: Tirzepatide, Placebo

Condition: Alcohol Use Disorder, Alcohol Abuse/Dependence, Alcohol Dependence, Alcoholism, Schizophrenia Disorders, Schizophrenia and Disorders With Psychotic Features, Schizophrenia and Schizophrenia Spectrum Psychosis, Schizophrenia

Sponsor: Anders Fink-Jensen, MD, DMSci

Locations: 2 active-listed locations

Effects of Tirzepatide on Muscle and Vascular Health in Obese Older Adults

Trial ID: NCT06811324   Registry: ClinicalTrials.gov

Intervention: Tirzepatide

Condition: Obesity Prevention, Sarcopenia in Elderly, Cardiovascular Function, GLP - 1, Weight Loss

Sponsor: The University of Texas Health Science Center at San Antonio

Locations: 1 active-listed location

Effects of a Collagen Supplement on Quality of Life, Appetite and Glycaemic Control

Trial ID: NCT07229014   Registry: ClinicalTrials.gov

Intervention: Collagen peptide supplement, Placebo

Condition: Quality of Life, Appetite, Sleep, Mood, Energy, Blood Glucose Profile

Sponsor: King's College London

Locations: 1 active-listed location

Efficacy and Safety of Autologous Peptide-induced Active Immunity in AML Maintenance Therapy

Trial ID: NCT07551037   Registry: ClinicalTrials.gov

Intervention: Active Immunotherapy, after 6 courses of routine consolidation chemotherapy, during 6 courses of routine consolidation chemotherapy

Condition: Acute Myeloid Leukemia, Personalized Active Immunotherapy, Maintenance Therapy

Sponsor: Fujian Medical University Union Hospital

Locations: 1 active-listed location

Efficacy of Electroacupuncture for Acute Herpes Zoster-Associated Pain and Biomarker Evaluation

Trial ID: NCT07515885   Registry: ClinicalTrials.gov

Intervention: Acupuncture, Sham, Valacyclovir, pregabalin and mecobalamin

Condition: Acute Herpes Zoster

Sponsor: Dexiong Han

Locations: 1 active-listed location

Efficacy of SALI-10 Oral Probiotics in Experimental Gingivitis

Trial ID: NCT07256743   Registry: ClinicalTrials.gov

Intervention: 6B SALI-10

Condition: Gingivitis

Sponsor: Ostia Sciences

Locations: 1 active-listed location

Efficacy of Transcutaneous Auricular Vagus Nerve Stimulation on Alleviating Major Depressive Disorder in Patients With Acute Coronary Syndrome After Percutaneous Coronary Intervention:A Prospective, Double-Blind,Randomized Controlled Study

Trial ID: NCT07454070   Registry: ClinicalTrials.gov

Intervention: Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) Intervention, sham Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) Control

Condition: Depressive Disorder (Per DSM-V Criteria, Mild-to-moderate), Acute Coronary Syndrome (ACS), Percutaneous Coronary Intervention (PCI), Depressive Disorder, Postoperative Psychological Distress, Heart Rate Variability (HRV), Inflammatory Factors, Randomized Controlled Trial (RCT)

Sponsor: Jing Han

Locations: 1 active-listed location

Efficacy, Safety, and Pharmacokinetics of Vericiguat in Pediatric Participants With Heart Failure Due to Left Ventricular Systolic Dysfunction (MK-1242-036)

Trial ID: NCT05714085   Registry: ClinicalTrials.gov

Intervention: Vericiguat tablet, Vericiguat suspension, Placebo tablet, Placebo suspension

Condition: Heart Failure, Left Ventricular Systolic Dysfunction

Sponsor: Merck Sharp & Dohme LLC

Locations: 109 active-listed locations

Evaluating Myelodysplastic Syndrome Risks in NET Patients Planned for Peptide Radionuclide Therapy

Trial ID: NCT06510868   Registry: ClinicalTrials.gov

Intervention: Peptide receptor radionuclide therapy (PRRT), Blood collection

Condition: Myelodysplastic Syndrome, Acute Myeloid Leukemia

Sponsor: University Health Network, Toronto

Locations: 1 active-listed location

Evaluating a New Peptide Therapy for Retinal Diseases: AMD, Diabetic Retinopathy, and Dystrophies

Trial ID: NCT06787482   Registry: ClinicalTrials.gov

Intervention: ACE Retino

Condition: Retinitis Pigmentosa (RP), Age Related Macular Degeneration, Diabetic Retinopathy

Sponsor: Ace Cells Lab Limited

Locations: 2 active-listed locations

Evaluation and Management of Cardio Toxicity in Oncologic Patients

Trial ID: NCT02818517   Registry: ClinicalTrials.gov

Intervention: ACE inhibitors, beta blockers

Condition: Heart Failure

Sponsor: Tel-Aviv Sourasky Medical Center

Locations: 1 active-listed location

Evaluation of Oral Collagen Peptides on Skin Barrier Function in Women

Trial ID: NCT07529249   Registry: ClinicalTrials.gov

Intervention: Investigational Product 1, Investigational Product 2, Placebo

Condition: Dry Skin, Sensitive Skin, Dry Skin in the Elderly, Dietary Supplement

Sponsor: Centre de Pharmacologie Clinique Applique a la Dermatologie

Locations: 1 active-listed location

Evaluation of Self-assembling Peptides Versus Amorphous Calcium Phosphate in the Treatment of White Spot Lesions

Trial ID: NCT07146464   Registry: ClinicalTrials.gov

Intervention: Self-Assembling Peptide P11-4 Self-Assembling Peptide P11-4 is a biomimetic material applied topically to white spot lesions on the enamel. It diffuses into the lesion body and forms a three-dimension

Condition: Dental Caries Tooth Demineralization, Post-Orthodontic Esthetic Defects

Sponsor: Ain Shams University

Locations: 1 active-listed location

Evaluation of a Peptide Cream on the Forearm Skin Recovery of Healthy Volunteers

Trial ID: NCT07614698   Registry: ClinicalTrials.gov

Intervention: Acetyl Hexapeptide-37, Placebo

Condition: Skin Barrier Disruption and Recovery

Sponsor: University of Split, School of Medicine

Locations: 1 active-listed location

Evaluation of a Plasma Marker (p-Tau217) for the Biological Diagnosis of Alzheimer's Disease, and Comparison With CSF Markers

Trial ID: NCT07071649   Registry: ClinicalTrials.gov

Intervention: blood withdrawal

Condition: Alzheimer's Disease, Biomarkers, Non-invasive Diagnosis, Phosphorylated Protein p-tau217

Sponsor: Centre Hospitalier Universitaire, Amiens

Locations: 1 active-listed location

Evaluation of the Safety and Efficacy of SALI-10 Probiotic Lozenges

Trial ID: NCT07508839   Registry: ClinicalTrials.gov

Intervention: 3B SALI-10 Lozenge, Placebo

Condition: Gingivitis, Halitosis

Sponsor: Ostia Sciences

Locations: 1 active-listed location

Examination of How the Duration of Fasting and Temporary Stopping of GLP-1 Medications Affect the Amount of Food Left in the Stomach in People Using Liraglutide (Injected), Semaglutide (Taken by Mouth) or Semaglutide (Injected)

Trial ID: NCT07225816   Registry: ClinicalTrials.gov

Intervention: Liraglutide, Oral Semaglutide, Semaglutide

Condition: Obesity

Sponsor: Novo Nordisk A/S

Locations: 1 active-listed location

Exploring Minor Proteins and Peptides in Human Milk: a Proteomic Analysis Across Lactation Stages

Trial ID: NCT06787963   Registry: ClinicalTrials.gov

Condition: Low Birthweight Infant, Preterm, Very Low Birth Weight Preterms

Sponsor: Maimónides Biomedical Research Institute of Córdoba

Locations: 2 active-listed locations

FAPi PET in Pancreatic Ductal Adenocarcinoma

Trial ID: NCT07342231   Registry: ClinicalTrials.gov

Intervention: Ga-68 FAPi PET/CT

Condition: Pancreatic Cancer, Adenocarcinoma Pancreas

Sponsor: Tata Memorial Hospital

Locations: 1 active-listed location

Faecal Autologous Capsule Transplantation for Type 1 Diabetes Mellitus

Trial ID: NCT07083882   Registry: ClinicalTrials.gov

Intervention: freezedried autologous encapsulated fecal microbiota transplantation, placebo matching capsule without microbial content

Condition: Type 1 Diabetes Mellitis, Type 1 Diabetes (T1D), Fecal Microbiota Therapy (FMT)

Sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Locations: 1 active-listed location

Fingolimod for Type 2 Diabetes Mellitus

Trial ID: NCT05307731   Registry: ClinicalTrials.gov

Intervention: Fingolimod, guideline-based treatment for DM

Condition: Diabetes Mellitus, Type 2

Sponsor: General Hospital of Shenyang Military Region

Locations: 1 active-listed location

Fluorine-18-AlphaVBeta6-Binding Peptide Positron Emission Tomography in Metastatic Non-Small Cell Lung Cancer

Trial ID: NCT05452005   Registry: ClinicalTrials.gov

Intervention: [18F]-αvβ6-BP

Condition: Lung Cancer, Lung Cancer Metastatic, Brain Metastases, Non Small Cell Lung Cancer

Sponsor: University of California, Davis

Locations: 1 active-listed location

Food and Fitness With Medicine (FFWM)

Trial ID: NCT07027995   Registry: ClinicalTrials.gov

Intervention: Exercise is Medicine (EIM), Culinary Education, Food is Medicine, Nutrition Counseling, Participant Website

Condition: Cardiovascular Kidney Metabolic Syndrome, Type 2 Diabetes

Sponsor: Ohio State University

Locations: 4 active-listed locations

Fortified Oral Rehydration Therapy for Pediatric Diarrhea

Trial ID: NCT06137014   Registry: ClinicalTrials.gov

Intervention: Fortified Oral Rehydration Therapy, Standard of Care Oral Rehydration Therapy

Condition: Acute Gastroenteritis

Sponsor: Paul A Breslin

Locations: 1 active-listed location

Function of Beta Cells in Early-onset Diabetes Mellitus

Trial ID: NCT07574138   Registry: ClinicalTrials.gov

Intervention: Monitor and observe the clinical progression and beta cell function

Condition: Type 2 Diabetes Mellitus (T2DM), Beta Cell Function

Sponsor: University Medical Center Ho Chi Minh City (UMC)

Locations: 1 active-listed location

FusionVAC22_01: Fusion Transcript-based Peptide Vaccine Combined with Immune Checkpoint Inhibition

Trial ID: NCT05937295   Registry: ClinicalTrials.gov

Intervention: Fusion-VAC-XS15

Condition: Fibrolamellar Hepatocellular Carcinoma

Sponsor: University Hospital Tuebingen

Locations: 1 active-listed location

GENESIS: Genotype Guided - Natriuretic Peptides - Cardiometabolic Health Study

Trial ID: NCT05216042   Registry: ClinicalTrials.gov

Intervention: Study diet, Exercise capacity VO2 max determination, Exercise Challenge, Glucose Challenge

Condition: Cardiovascular Diseases, Natriuretic Peptides, Cardiometabolic Diseases, Energy Expenditure, Glucose Metabolism, Exercise, Obesity

Sponsor: University of Alabama at Birmingham

Locations: 1 active-listed location

GIP/GLP-1RA as Adjunctive to Automated Insulin Delivery in Adults With Type 1 Diabetes

Trial ID: NCT06630585   Registry: ClinicalTrials.gov

Intervention: Tirzepatide

Condition: Type 1 Diabetes (T1D)

Sponsor: University of Bern

Locations: 3 active-listed locations

GLP-1 Receptor Agonist Use and Sarcopenia in Obese Individuals Without Diabetes

Trial ID: NCT07858864   Registry: ClinicalTrials.gov

Intervention: GLP-1 receptor agonist (e.g., semaglutide, tirzepatide) - prescribed by the treating physician as standard care; the study does not assign or alter treatment.

Condition: Obesity, Sarcopenia

Sponsor: Istanbul Saglik Bilimleri University

Locations: 1 active-listed location

GLP-1 Receptor Agonist for Reduction of Myocardial Injury After Non-cardiac Surgery

Trial ID: NCT06324461   Registry: ClinicalTrials.gov

Intervention: Dulaglutide 0.75mg subcutaneous injection

Condition: Myocardial Injury

Sponsor: The University of Hong Kong

Locations: 3 active-listed locations

GLP-1Ra Impact on Metabolic Outcomes in Stage 2 T1DM While Receiving Teplizumab

Trial ID: NCT06338553   Registry: ClinicalTrials.gov

Intervention: Semaglutide (Rybelsus®), Placebo

Condition: Type 1 Diabetes

Sponsor: Vanderbilt University Medical Center

Locations: 1 active-listed location

GMP Powdered Substitutes in PKU and TYR

Trial ID: NCT06941532   Registry: ClinicalTrials.gov

Intervention: GMP Intervention Product

Condition: Phenylketonuria, Tyrosinemia

Sponsor: Nutricia UK Ltd

Locations: 1 active-listed location

Genetic and Immunity in Heart Failure

Trial ID: NCT06758128   Registry: ClinicalTrials.gov

Intervention: Evaluation of HS1,2 polymorphisms

Condition: Heart Failure

Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Locations: 2 active-listed locations

Glucagon-Like Peptide-1 Receptor Agonist in ADPKD

Trial ID: NCT06582875   Registry: ClinicalTrials.gov

Intervention: Tirzepatide, Placebo

Condition: Autosomal Dominant Polycystic Kidney, Obesity

Sponsor: University of Colorado, Denver

Locations: 1 active-listed location

Glucagon-like Peptide 1 (GLP-1) Receptor Agonist Therapy and Exercise Training in People With Obesity

Trial ID: NCT07091500   Registry: ClinicalTrials.gov

Intervention: Exercise training, Semaglutide, Therapy Cessation

Condition: Obesity, Skeletal Muscle, Brain Connectivity

Sponsor: Washington University School of Medicine

Locations: 1 active-listed location

Glucagon-like Peptide-1 Receptor Agonist (GLP-1 RA) and Diet in Inflammatory Bowel Disease (IBD) Patients

Trial ID: NCT06774079   Registry: ClinicalTrials.gov

Intervention: Tirzepatide, Mediterranean diet

Condition: Crohn Disease

Sponsor: University of Miami

Locations: 1 active-listed location

Gluten Challenge in Celiac Disease - Which Formulation of Gluten Gives the Best Response?

Trial ID: NCT07039773   Registry: ClinicalTrials.gov

Intervention: Vital wheat gluten

Condition: Celiac Disease

Sponsor: Oslo University Hospital

Locations: 2 active-listed locations

Growth and Tolerance of Plant-based Enteral Formulas in Children Ages 12-17 Months.

Trial ID: NCT07231705   Registry: ClinicalTrials.gov

Intervention: Kate Farms Standard 1.2 or Peptide 1.0

Condition: Formula Dependent Children 1 to 2 Years of Age

Sponsor: Kate Farms Inc

Locations: 1 active-listed location

HER-2 B Cell Peptide Vaccine

Trial ID: NCT06414733   Registry: ClinicalTrials.gov

Intervention: Combination of MVF-HER-2 (597-626) and MVF-HER-2 (266-296) emulsified with ISA 51

Condition: Metastatic Breast Cancer, HER2-positive Breast Cancer, EGFR Overexpression, Metastatic Esophageal Carcinoma, HER-2 Positive Esophageal Cancer

Sponsor: Pravin T.P Kaumaya

Locations: 1 active-listed location

Healthy Volunteers Enteral Nutrition Study (HEN)

Trial ID: NCT07426003   Registry: ClinicalTrials.gov

Intervention: Kate Farms Peptide 1.5, Crohn's disease exclusion diet

Condition: Enteral Nutrition's Effect on the Gut

Sponsor: James Lewis

Locations: 1 active-listed location

How is Aerobic Exercise Compared to Localized Pain Relief Exercises in Patients With Jaw Pain and Neck Pain?

Trial ID: NCT05232604   Registry: ClinicalTrials.gov

Intervention: Aerobic exercise, Neck motor control exercise

Condition: Temporomandibular Disorder, Neck Pain

Sponsor: Hochschule Osnabruck

Locations: 1 active-listed location

Human Clinical Trial Evaluating the Blood Glucose-Regulating Effects of Momordica Charantia Peptides

Trial ID: NCT07504029   Registry: ClinicalTrials.gov

Intervention: BmpP® Momordica charantia Peptide Capsules

Condition: People With Prediabetic

Sponsor: Chung Shan Medical University

Locations: 1 active-listed location

Hypersensitivity to Adrenomedullin in Post-Traumatic Headache

Trial ID: NCT07059546   Registry: ClinicalTrials.gov

Intervention: Adrenomedullin, Placebo

Condition: Posttraumatic Headache

Sponsor: Danish Headache Center

Locations: 1 active-listed location

INSL3 as a Biomarker of Pubertal Activation: Role in Evaluating Precocious and Delayed Puberty

Trial ID: NCT07859787   Registry: ClinicalTrials.gov

Condition: Precocious Puberty, Central, Delayed Puberty

Sponsor: IRCCS Azienda Ospedaliero-Universitaria di Bologna

Locations: 1 active-listed location

Identification of a Score for the Assessment of Intrapancreatic Fat

Trial ID: NCT07155473   Registry: ClinicalTrials.gov

Intervention: C-peptide dosage

Condition: Pancreatic Steatosis, Metabolic Syndrome X, Diabetes

Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Locations: 3 active-listed locations

Imaging CRF X NOP Interactions in CUD

Trial ID: NCT05008146   Registry: ClinicalTrials.gov

Intervention: Baseline [C-11]NOP-1A PET Scan, Hydrocortisone, Post-hydrocortisone [C-11]NOP-1A PET Scan

Condition: Cocaine Use Disorder

Sponsor: Rajesh Narendran

Locations: 1 active-listed location

Imaging Versus Cardiac Biomarker Monitored HER2 Directed Therapy in Patients With Breast Cancer

Trial ID: NCT05406635   Registry: ClinicalTrials.gov

Intervention: Biomarkers: Troponins and natriuretic peptides

Condition: Cardiotoxicity, HER2-positive Breast Cancer

Sponsor: Odense University Hospital

Locations: 4 active-listed locations

Imaging of Solid Tumors Using FAP-2286

Trial ID: NCT04621435   Registry: ClinicalTrials.gov

Intervention: Gallium-68 labelled (68Ga-) FAP-2286, Positron Emission Tomography (PET) imaging, Copper-64 labeled (64Cu-) FAP-2286

Condition: Solid Tumors, Adult, Metastatic Cancer

Sponsor: Thomas Hope

Locations: 1 active-listed location

Impact GLP-1 Agonists Following Bariatric

Trial ID: NCT06132477   Registry: ClinicalTrials.gov

Intervention: GLP-1 receptor agonist

Condition: Morbid Obesity, Metabolic Syndrome, Diabetes Mellitus, Hypertension, Obstructive Sleep Apnea of Adult

Sponsor: University of Missouri-Columbia

Locations: 1 active-listed location

Impact of Aorto-Iliac Occlusive Disease Treatment on Blood Pressure

Trial ID: NCT07070583   Registry: ClinicalTrials.gov

Intervention: Stent placement

Condition: Aorto Iliac Occlusive Disease, Blood Pressure

Sponsor: Rijnstate Hospital

Locations: 1 active-listed location

Impact of Genetic Variants on the Toxicity of Antibody-Drug Conjugates in Locally Advanced or Metastatic Breast Cancer: The Role of the UGT1A1 Gene as a Predictive Biomarker of Therapeutic Response

Trial ID: NCT07582887   Registry: ClinicalTrials.gov

Intervention: Sacituzumab Govitecan, Trastuzumab deruxtecan, Datopotamab Deruxtecan

Condition: Breast Cancer, Metastatic Breast Cancer, Drug-Related Side Effects and Adverse Reactions, Pharmacogenetic Variant

Sponsor: Fundación Pública Andaluza para la Investigación Biomédica Andalucía Oriental

Locations: 1 active-listed location

Improving Peptide Receptor Radionuclide Therapy With PARP Inhibitors

Trial ID: NCT05870423   Registry: ClinicalTrials.gov

Intervention: olaparib

Condition: Neuroendocrine Tumors, Peptide Receptor Radionuclide Therapy

Sponsor: Erasmus Medical Center

Locations: 1 active-listed location

Individualized Neoantigen Therapy with Unusual Radiotherapy Enhancement (iNATURE)

Trial ID: NCT06314087   Registry: ClinicalTrials.gov

Intervention: Placebo + conventional treatment including radiotherapy, Radiation: Radiation Therapy；Biological: Personalized tumor peptide vaccine

Condition: Advanced Tumors

Sponsor: The University of Hong Kong-Shenzhen Hospital

Locations: 2 active-listed locations

Induction of Migraine Attacks With Aura Using Calcitonin Gene-Related Peptide

Trial ID: NCT07021859   Registry: ClinicalTrials.gov

Intervention: Calcitonin-gene related peptide (CGRP), Placebo

Condition: Migraine Aura, Migraine With Aura

Sponsor: Danish Headache Center

Locations: 1 active-listed location

Integrated Digital and Neurogenic Exosome Biomarkers for Early Diagnosis of Parkinson's Disease: Development and Application

Trial ID: NCT07679256   Registry: ClinicalTrials.gov

Condition: PARKINSON DISEASE (Disorder)

Sponsor: Fujian Medical University Union Hospital

Locations: 1 active-listed location

Interleukine-2 (IL-2) Plus Semaglutide in Alzheimer's Disease

Trial ID: NCT07651319   Registry: ClinicalTrials.gov

Intervention: IL-2 (Aldesleukin), Semaglutide Plus IL-2, Placebo

Condition: Alzheimer Dementia (AD)

Sponsor: The Methodist Hospital Research Institute

Locations: 1 active-listed location

Intra-arterial Hepatic (IAH) Infusion of Radiolabelled Somatostatin Analogs in GEP-NET Patients With Dominant Liver Metastases

Trial ID: NCT04837885   Registry: ClinicalTrials.gov

Intervention: Positron emission tomography computed tomography (PET/CT) with Intra-hepatic (IAH) injection, Positron emission tomography computed tomography (PET/CT) with Intravenous (IV) injection, LUTATHERA® by intra-arterial hepatic (IAH) injection, Scan

Condition: Neuroendocrine Tumor, Liver Metastases, Neuroendocrine Gastroenteropancreatic Tumour

Sponsor: University Hospital, Bordeaux

Locations: 4 active-listed locations

Intranasal Oxytocin Intervention for Caregivers to Persons With Dementia

Trial ID: NCT06364228   Registry: ClinicalTrials.gov

Intervention: Placebo, Oxytocin Intranasal Spray 12 International Unit (12IU), Oxytocin Intranasal Spray 24 International Unit (24IU), Functional MRI

Condition: Stress

Sponsor: University of Nebraska

Locations: 1 active-listed location

KRAS Neoantigen Nanovaccine as Adjuvant Therapy for Colorectal Cancer/Pancreatic Cancer

Trial ID: NCT07353645   Registry: ClinicalTrials.gov

Intervention: KRAS Neoantigen Nanovaccine

Condition: Colorectal Cancer, Pancreatic Cancer

Sponsor: The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School

Locations: 1 active-listed location

KRAS-Targeted Vaccine Combined With Balstilimab and Botensilimab for Patients With Stage IV MMR-p Colorectal Cancer and Pancreatic Ductal Cancer

Trial ID: NCT06411691   Registry: ClinicalTrials.gov

Intervention: KRAS Vaccine with Poly-ICLC adjuvant, Balstilimab, Botensilimab

Condition: Colorectal Cancer, Pancreatic Cancer

Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Locations: 1 active-listed location

KRAS-Targeted Vaccine With Chemoimmunotherapy, Nivolumab and Ipilimumab for Patients With NSCLC

Trial ID: NCT05254184   Registry: ClinicalTrials.gov

Intervention: Pooled Mutant KRAS-Targeted Long Peptide Vaccine 0.3mg each; 1.8mg total peptides

Condition: Non-Small Cell Lung Cancer

Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Locations: 1 active-listed location

LSALT Peptide for Prevention or Attenuation of Acute Kidney Injury (AKI) in Patients Undergoing On-Pump Cardiac Surgery

Trial ID: NCT05879432   Registry: ClinicalTrials.gov

Intervention: LSALT Peptide, Placebo

Condition: Acute Kidney Injury, Cardiac Surgery

Sponsor: Arch Biopartners Inc.

Locations: 9 active-listed locations

Low Level Tragus Stimulation in Acute Decompensated Heart Failure

Trial ID: NCT02898181   Registry: ClinicalTrials.gov

Intervention: Neuromodulation

Condition: Acute Decompensated Heart Failure

Sponsor: University of Oklahoma

Locations: 1 active-listed location

MB-dNPM1-TCR.1 in Relapsed/Refractory AML

Trial ID: NCT06424340   Registry: ClinicalTrials.gov

Intervention: MB-dNPM1-TCR.1

Condition: Leukemia, Myeloid, Acute

Sponsor: Miltenyi Biomedicine GmbH

Locations: 1 active-listed location

MIMA Pilot Study: MIcrostructure of the Medial Temporal Lobe in Early Alzheimer's Disease

Trial ID: NCT06099587   Registry: ClinicalTrials.gov

Intervention: high-resolution diffusion MRI

Condition: Alzheimer Disease, Early Onset

Sponsor: Rennes University Hospital

Locations: 1 active-listed location

ML Score Prediction of Cardiotoxicity in Cancer Patients Receiving Anthracycline Chemotherapy or HER2-Targeted Therapies

Trial ID: NCT07191730   Registry: ClinicalTrials.gov

Condition: Cardiotoxicity, Heart Failure, Neoplasms, Breast Neoplasms

Sponsor: University Hospital, Caen

Locations: 1 active-listed location

MMP14(MT1-MMP) Targeting Bicyclic Peptide Probe for PET Imaging in Solid Tumors

Trial ID: NCT06719856   Registry: ClinicalTrials.gov

Intervention: 18-FDG

Condition: Solid Tumor

Sponsor: Peking University Cancer Hospital & Institute

Locations: 1 active-listed location

MR Evidence of Cardiac Inflammation Post-Stroke

Trial ID: NCT05714618   Registry: ClinicalTrials.gov

Intervention: Gadolinium-enhanced cardiac MRI, B Natriuretic Peptide, Systemic inflammatory markers

Condition: Stroke, Ischemic, Inflammation, Myocardial Injury

Sponsor: Luciano A. Sposato

Locations: 1 active-listed location

Maternal Characteristics Associated With Child Growth and Adiposity

Trial ID: NCT05798676   Registry: ClinicalTrials.gov

Intervention: overweight/obesity

Condition: Obesity, Obesity, Infant

Sponsor: Instituto de Desarrollo e Investigaciones Pediátricas Prof. Dr. Fernando E. Viteri

Locations: 1 active-listed location

Mathematical Modeling of Blood Sugar and Hormone Responses in Insulin-Dependent Type 2 Diabetes

Trial ID: NCT07650682   Registry: ClinicalTrials.gov

Condition: Type 2 Diabetes, Insulin Dependent Diabetes

Sponsor: Clinical Nutrition Research Center, Illinois Institute of Technology

Locations: 1 active-listed location

Measurement Of NT-proBNP to Predict Outcomes in Surgery

Trial ID: NCT04014647   Registry: ClinicalTrials.gov

Condition: Vascular Surgical Procedure

Sponsor: Norfolk and Norwich University Hospitals NHS Foundation Trust

Locations: 1 active-listed location

Metabolic Effects of Angiotensin-(1-7)

Trial ID: NCT02646475   Registry: ClinicalTrials.gov

Intervention: Angiotensin-(1-7), Saline

Condition: Obesity, Insulin Resistance, Hypertension, Metabolic Cardiovascular Syndrome

Sponsor: Vanderbilt University

Locations: 1 active-listed location

Metabolic Interventions (Time-Restricted Eating, GLP1 Receptor Agonist, and Heart Healthy Diet) to Improve Cardiometabolic Health in Prostate Cancer Patients During Androgen Deprivation Therapy, IMPACT-ADT Trial

Trial ID: NCT07202247   Registry: ClinicalTrials.gov

Intervention: Antiandrogen Therapy, Behavioral Intervention, Biospecimen Collection, Cardiac Computerized Tomographic Angiography, Computed Tomography, Electronic Health Record Review, Internet-Based Intervention, Lifestyle Counseling, Medical Device Usage and Evaluation, Nutritional Intervention, Questionnaire Administration, Radiation Therapy, Referral, Semaglutide, Short-Term Fasting, Tirzepatide

Condition: Prostate Carcinoma, Recurrent Prostate Carcinoma

Sponsor: City of Hope Medical Center

Locations: 10 active-listed locations

Molecular Basis of Human Phagocyte Interactions With Bacterial Pathogens

Trial ID: NCT00339287   Registry: ClinicalTrials.gov

Condition: Host Defense Mechanisms

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Locations: 1 active-listed location

Monocytes in Subjects With Type 1 Diabetes and Chronic Kidney Disease

Trial ID: NCT06694558   Registry: ClinicalTrials.gov

Condition: Chronic Kidney Disease(CKD), Type 1 Diabetes (T1D)

Sponsor: The Cleveland Clinic

Locations: 1 active-listed location

Multi-antigen CMV-Modified Vaccinia Ankara Vaccine in Treating Pediatric Patients With Positive Cytomegalovirus Undergoing Donor Stem Cell Transplant

Trial ID: NCT03354728   Registry: ClinicalTrials.gov

Intervention: Laboratory Biomarker Analysis, Multi-peptide CMV-Modified Vaccinia Ankara Vaccine

Condition: Cytomegaloviral Infection, Hematopoietic Cell Transplant Recipient

Sponsor: City of Hope Medical Center

Locations: 1 active-listed location

Multidisciplinary Approach for High Risk Patients Leading to Early Diagnosis of Canadians in Heart Failure

Trial ID: NCT05859048   Registry: ClinicalTrials.gov

Intervention: NT-proBNP, AI echocardiogram, electrocardiogram, Cardiovascular physical examination

Condition: Heart Failure

Sponsor: Cardiology Research UBC

Locations: 3 active-listed locations

NAUTICAL: Effect of Natriuretic Peptide Augmentation on Cardiometabolic Health in Black Individuals

Trial ID: NCT04055428   Registry: ClinicalTrials.gov

Intervention: Sacubitril, Valsartan 97-103 mg Oral Tablet, Valsartan 160 mg, Intravenous Glucose Tolerance Test, Standardized Meals, Exercise capacity VO2 maximum determination

Condition: Diabetes Mellitus, Cardiovascular Diseases, Insulin Sensitivity/Resistance, Metabolic Disease, Natriuretic Peptides, Metabolism, Energy Expenditure

Sponsor: University of Alabama at Birmingham

Locations: 1 active-listed location

NRSTS2021, A Risk Adapted Study Evaluating Maintenance Pazopanib, Limited Margin, Dose-Escalated Radiation Therapy and Selinexor in Non-Rhabdomyosarcoma Soft Tissue Sarcoma (NRSTS)

Trial ID: NCT06239272   Registry: ClinicalTrials.gov

Intervention: Surgical resection, Proton beam radiation therapy, Pazopanib, Ifosfamide, Doxorubicin, Selinexor

Condition: Adipocytic Neoplasm, Liposarcoma, Atypical Fibroxanthoma, Angiomatoid Fibrous Histiocytoma, Fibrosarcoma NOS, Myxofibrosarcoma, Angiosarcoma, Osteosarcoma, Extraskeletal, Dedifferentiated Liposarcoma, Myxoid Liposarcoma, Pleomorphic Liposarcoma, Myxoid Pleomorphic Liposarcoma, Low Grade Fibromyxoid Sarcoma, Sclerosing Epithelioid Fibrosarcoma, Malignant Tenosynovial Giant Cell Tumor of Soft Tissue, Epithelioid Hemangioendothelioma, Glomus Tumor, Inflammatory Leiomyosarcoma, Leiomyosarcoma, Ossifying Fibromyxoid Tumor, Malignant, Myoepithelioma, Synovial Sarcoma, Epithelioid Sarcoma, Perineurioma, Malignant, Clear Cell Sarcoma, Extraskeletal Myxoid Chondrosarcoma, Granular Cell Tumor, Malignant, Melanotic Malignant Nerve Sheath Tumor, Malignant Peripheral Nerve Sheath Tumor, Perivascular Epithelioid Tumor, Malignant, Intimal Sarcoma, Myoepithelial Carcinoma, Undifferentiated Sarcoma, Pleomorphic Sarcoma, Undifferentiated, Round Cell Sarcoma, Undifferentiated, NTRK-Rearranged Spindle Cell Neoplasm, Phosphaturic Mesenchymal Tumor, Malignant, Round Cell Sarcoma, Well Differentiated Liposarcoma, Giant Cell Tumor of Soft Parts NOS, Low Grade Myofibroblastic Sarcoma, Dermatofibrosarcoma Protuberans, Fibrosarcomatous

Sponsor: St. Jude Children's Research Hospital

Locations: 7 active-listed locations

NT-proBNP Selected Prevention of Cardiac Events in Diabetic Patients

Trial ID: NCT02817360   Registry: ClinicalTrials.gov

Intervention: RAS-antagonist and beta-blocker up-to maximal dosages, RAS-antagonist and beta-blocker none or at stable dose

Condition: Heart Diseases, Diabetes Mellitus, Type 2

Sponsor: Martin Huelsmann

Locations: 21 active-listed locations

National Cohort of Subjects at Risk of Developing Rheumatoid Arthritis

Trial ID: NCT06876064   Registry: ClinicalTrials.gov

Intervention: Blood test, Urine test, stool collection, saliva collection, Induced expectoration, Hair and nails sampling, Schirmer test, Ultrasound of hands and feet, MRI Contrast, Patient questions, Dental panoramic X-ray, Consultation with a psychologist in certain centers, Measurement of heart rate variability., Behavioral: semi-structured psychological interview (1 h, teleconsultation)

Condition: Rheumatoid Arthritis (RA)

Sponsor: University Hospital, Montpellier

Locations: 1 active-listed location

Neoantigen-based Peptide Vaccine and Conventional Second-line Therapy for CRC Progressed After First-line Treatment

Trial ID: NCT06751914   Registry: ClinicalTrials.gov

Intervention: Conventional second-line therapy, Neoantigen-based peptide vaccine

Condition: Colorectal Cancer (CRC)

Sponsor: The First Affiliated Hospital of Nanchang University

Locations: 2 active-listed locations

Neoantigen-based Peptide Vaccine and Conventional Third-line Therapy for CRC Progressed After Second-line Treatment

Trial ID: NCT06751966   Registry: ClinicalTrials.gov

Intervention: Combination Product: Conventional third-line therapy, Neoantigen-based peptide vaccine

Condition: Colorectal Cancer (CRC)

Sponsor: The First Affiliated Hospital of Nanchang University

Locations: 2 active-listed locations

Neoantigen-based Peptide Vaccine, PD-1 Inhibitor, and Radiotherapy for Advanced NSCLC Progressed After First-line Treatment

Trial ID: NCT06752044   Registry: ClinicalTrials.gov

Intervention: Radiotherapy, PD-1 inhibitor, Neoantigen-based peptide vaccine

Condition: Advanced NSCLC

Sponsor: The First Affiliated Hospital of Nanchang University

Locations: 2 active-listed locations

Neoantigen-based Peptide Vaccine, PD-1 Inhibitor, and Radiotherapy for Advanced NSCLC Progressed After Second-line Treatment

Trial ID: NCT06751901   Registry: ClinicalTrials.gov

Intervention: Radiotherapy, PD-1 inhibitor, Neoantigen-based peptide vaccine

Condition: Advanced NSCLC

Sponsor: The First Affiliated Hospital of Nanchang University

Locations: 2 active-listed locations

Nesiritide in Hypertension

Trial ID: NCT02608996   Registry: ClinicalTrials.gov

Intervention: Nesiritide, Placebo

Condition: Hypertension

Sponsor: Oslo University Hospital

Locations: 3 active-listed locations

New CSF Biomarkers for Alzheimer's Disease

Trial ID: NCT03621839   Registry: ClinicalTrials.gov

Condition: Alzheimer Disease, Dementia, Neurodegenerative Diseases

Sponsor: Central Hospital, Nancy, France

Locations: 1 active-listed location

New Therapeutic Strategy Against Preeclampsia

Trial ID: NCT06464159   Registry: ClinicalTrials.gov

Intervention: Biological collection

Condition: Preeclampsia

Sponsor: Assistance Publique - Hôpitaux de Paris

Locations: 1 active-listed location

Novel Antisense Oligonucleotide Eye Drops for Treating Antibiotic-Resistant Bacterial Keratitis

Trial ID: NCT06451172   Registry: ClinicalTrials.gov

Intervention: ASO

Condition: Bacterial Keratitis, Antibiotic-resistant Bacteria, Infections, Bacterial, Corneal Diseases, Eye Diseases, Vision Disorders, Sensation Disorders, Blindness, Antisense Peptide Nucleic Acid, Antibacterial Therapy

Sponsor: Eye & ENT Hospital of Fudan University

Locations: 1 active-listed location

Open-Label Study of Dimethyl Fumarate in Adults With Type 1 Diabetes

Trial ID: NCT07548996   Registry: ClinicalTrials.gov

Intervention: Dimethyl Fumarate Enteric-coated Capsules, Insulin

Condition: Type 1 Diabetes Mellitus

Sponsor: Nanjing Medical University

Locations: 1 active-listed location

Oromucosal Oxytocin and Vasopressin Modulation of Emotional Face Attention

Trial ID: NCT07838493   Registry: ClinicalTrials.gov

Intervention: Oxytocin (OT), Arginine Vasopressin (AVP), Placebo (PLC)

Condition: Healhty

Sponsor: University of Electronic Science and Technology of China

Locations: 1 active-listed location

Oxytocin and Reward Processing in Women

Trial ID: NCT06222749   Registry: ClinicalTrials.gov

Intervention: Intranasal oxytocin administration, Intranasal placebo administration

Condition: Menstrual Cycle, Hormonal Contraception

Sponsor: International Research Training Group 2804

Locations: 1 active-listed location